Opioids, Neutral Endopeptidase, Its Inhibitors and Cancer: Is There a Relationship Among Them?

Overview

Journal Arch Immunol Ther Exp (Warsz)

Publisher Sciendo

Specialty Allergy & Immunology

Date 2014 Sep 7

PMID 25193979

Citations 4

Authors

Magdalena Mizerska-Dudka

Martyna Kandefer-Szerszen

Affiliations

Soon will be listed here.

Abstract

The role of endogenous animal opioids in the biology of cancer is widely recognized but poorly understood. This is, among others, because of the short half-life of these peptides, which are quickly inactivated by endopeptidases, e.g., neutral endopeptidase (NEP, CD10). It has been established that NEP is engaged in the modulation of the tumor microenvironment, among others that of colon cancer, by exerting influence on cell growth factors, the extracellular matrix and other biologically active substances. Although there are some discrepancies among the findings on the role of both opioids and NEP in cancer development, authors agree that their role seems to depend on the origin, stage and grade of tumor, and even on the method of examination. Moreover, recently, natural inhibitors of NEP, such as sialorphin, opiorphin and spinorphin have been detected. Their analgesic activity has been established. It is interesting to ask whether there is a relationship among opioid peptides, tumor-associated NEP and its inhibitors.

Citing Articles

A comprehensive review of the literature on CD10: its function, clinical application, and prospects.

Wang S, Xiao Y, An X, Luo L, Gong K, Yu D Front Pharmacol. 2024; 15:1336310.

PMID: 38389922 PMC: 10881666. DOI: 10.3389/fphar.2024.1336310.

An Early Neoplasia Index (ENI10), Based on Molecular Identity of CD10 Cells and Associated Stemness Biomarkers, is a Predictor of Patient Outcome in Many Cancers.

Guyot B, Clement F, Drouet Y, Schmidt X, Lefort S, Delay E Cancer Res Commun. 2023; 3(9):1966-1980.

PMID: 37707389 PMC: 10540743. DOI: 10.1158/2767-9764.CRC-23-0196.

is essential for xenograft tumor development in mice injected with the human prostate cancer cell-line, LNCaP, and modulates cell migration and invasion.

Mukherjee A, Park A, Davies K J Mens Health. 2022; 18(2).

PMID: 35547856 PMC: 9089447. DOI: 10.31083/jomh.2021.131.

Role of opiorphin genes in prostate cancer growth and progression.

Mukherjee A, Park A, Wang L, Davies K Future Oncol. 2021; 17(17):2209-2223.

PMID: 33593085 PMC: 8293029. DOI: 10.2217/fon-2020-1299.

References

Colucci R, Blandizzi C, Ghisu N, Florio T, Del Tacca M . Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation. Br J Pharmacol. 2008; 155(2):198-209. PMC: 2538699. DOI: 10.1038/bjp.2008.268. View

Tabellini G, Borsani E, Benassi M, Patrizi O, Ricotta D, Caimi L . Effects of opioid therapy on human natural killer cells. Int Immunopharmacol. 2013; 18(1):169-74. DOI: 10.1016/j.intimp.2013.11.015. View

Rougeot C, Robert F, Menz L, Bisson J, Messaoudi M . Systemically active human opiorphin is a potent yet non-addictive analgesic without drug tolerance effects. J Physiol Pharmacol. 2010; 61(4):483-90. View

Fujimoto Y, Nakanishi Y, Sekine S, Yoshimura K, Akasu T, Moriya Y . CD10 expression in colorectal carcinoma correlates with liver metastasis. Dis Colon Rectum. 2005; 48(10):1883-9. DOI: 10.1007/s10350-005-0141-6. View

Chen H, Noble F, Roques B, Fournie-Zaluski M . Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs. J Med Chem. 2001; 44(21):3523-30. DOI: 10.1021/jm0102248. View

Isayama T, McLaughlin P, Zagon I . Endogenous opioids regulate cell proliferation in the retina of developing rat. Brain Res. 1991; 544(1):79-85. DOI: 10.1016/0006-8993(91)90887-2. View

Yao T, Takata M, Tustsumi S, Nishiyama K, Taguchi K, Nagai E . Phenotypic expression of gastrointestinal differentiation markers in colorectal adenocarcinomas with liver metastasis. Pathology. 2003; 34(6):556-60. DOI: 10.1080/0031302021000035965-4. View

Zagon I, Verderame M, McLaughlin P . The biology of the opioid growth factor receptor (OGFr). Brain Res Brain Res Rev. 2002; 38(3):351-76. DOI: 10.1016/s0165-0173(01)00160-6. View

McLaughlin P, Levin R, Zagon I . Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor. Int J Oncol. 1999; 14(5):991-8. DOI: 10.3892/ijo.14.5.991. View

10.

Oshima T, Kawasaki T, Ohashi R, Hasegawa G, Jiang S, Umezu H . Downregulated P1 promoter-driven hepatocyte nuclear factor-4alpha expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. Pathol Int. 2007; 57(2):82-90. DOI: 10.1111/j.1440-1827.2006.02061.x. View

11.

Zagon I, McLaughlin P . Endogenous opioid systems regulate growth of neural tumor cells in culture. Brain Res. 1989; 490(1):14-25. DOI: 10.1016/0006-8993(89)90425-3. View

12.

Honda M, Okutsu H, Matsuura T, Miyagi T, Yamamoto Y, Hazato T . Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn J Pharmacol. 2002; 87(4):261-7. DOI: 10.1254/jjp.87.261. View

13.

Zagon I, McLaughlin P, Goodman S, Rhodes R . Opioid receptors and endogenous opioids in diverse human and animal cancers. J Natl Cancer Inst. 1987; 79(5):1059-65. View

14.

Iwata N, Tsubuki S, Takaki Y, SHIROTANI K, Lu B, Gerard N . Metabolic regulation of brain Abeta by neprilysin. Science. 2001; 292(5521):1550-2. DOI: 10.1126/science.1059946. View

15.

Li W, Chen W, Herberman R, Plotnikoff N, Youkilis G, Griffin N . Immunotherapy of cancer via mediation of cytotoxic T lymphocytes by methionine enkephalin (MENK). Cancer Lett. 2013; 344(2):212-22. DOI: 10.1016/j.canlet.2013.10.029. View

16.

Morris K, Kuo B, Wilkinson M, Davison J, Befus A, Mathison R . Vcsa1 gene peptides for the treatment of inflammatory and allergic reactions. Recent Pat Inflamm Allergy Drug Discov. 2008; 1(2):124-32. DOI: 10.2174/187221307780979892. View

17.

Ogawa H, Iwaya K, Izumi M, Kuroda M, Serizawa H, Koyanagi Y . Expression of CD10 by stromal cells during colorectal tumor development. Hum Pathol. 2002; 33(8):806-11. DOI: 10.1053/hupa.2002.125773. View

18.

Sumitomo M, Iwase A, Zheng R, Navarro D, Kaminetzky D, Shen R . Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN. Cancer Cell. 2004; 5(1):67-78. DOI: 10.1016/s1535-6108(03)00331-3. View

19.

Nishimura K, Hazato T . [Spinorphin, a new inhibitor of enkephalin-degrading enzymes derived from the bovine spinal cord]. Masui. 1993; 42(10):1497-503. View

20.

Razak K, Newland A . Induction of CD13 expression on fresh myeloid leukaemia: correlation of CD13 expression with aminopeptidase-N activity. Leuk Res. 1992; 16(6-7):625-30. DOI: 10.1016/0145-2126(92)90012-v. View