Arabidopsis Voltage-dependent Anion Channel 1 (AtVDAC1) is Required for Female Development and Maintenance of Mitochondrial Functions Related to Energy-transaction

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Sep 6

PMID 25192453

Citations 11

Authors

Xiaodi Pan

Ziwei Chen

Xueyong Yang

Guoqin Liu

Affiliations

Soon will be listed here.

Abstract

The voltage-dependent anion channels (VDACs), prominently localized in the outer mitochondrial membrane, play important roles in the metabolite exchange, energy metabolism and mitochondria-mediated apoptosis process in mammalian cells. However, relatively little is known about the functions of VDACs in plants. To further investigate the function of AtVDAC1 in Arabidopsis, we analyzed a T-DNA insertion line for the AtVDAC1 gene. The knock-out mutant atvdac1 showed reduced seed set due to a large number of undeveloped ovules in siliques. Genetic analyses indicated that the mutation of AtVDAC1 affected female fertility and belonged to a sporophytic mutation. Abnormal ovules in the process of female gametogenesis were observed using a confocal laser scanning microscope. Interestingly, both mitochondrial transmembrane potential (ΔΨ) and ATP synthesis rate were obviously reduced in the mitochondria isolated from atvdac1 plants.

Citing Articles

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Xu J, Zhang Y, Ren H, Yu R, Yuan C, Hu Y Int J Mol Sci. 2021; 22(21).

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Voltage-Dependent Anion Channels (VDACs): Overlapping and Specific Functions in Mitochondria.

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