Correlation Between Hs-CRP and Asthma Control Indices

Overview

Journal Tanaffos

Specialty Pulmonary Medicine

Date 2014 Sep 6

PMID 25191472

Citations 4

Authors

Naseh Sigari

Hooman Ghasri

Affiliations

Soon will be listed here.

Abstract

Background: Local and systemic inflammation occur at the same time in asthma and high sensitive CRP may play a role in the pathogenesis of this disease. Conventional approaches to monitor and control asthma involve no direct assessment of airway inflammation. There are some recent data postulating a discrepancy between the markers of airway and systemic inflammation and asthma control test (ACT) scores. In this study we evaluate the correlation between the serum levels of hs-CRP in patients with different levels of asthma control based on ACT scores and spirometric indices.

Materials And Methods: The validated Persian version of ACT was administered to one-hundred asthmatic patients. Spirometry was performed and prebronchodilatory FEV1 was measured. Blood samples for CRP measurement were taken and hs-CRP levels were analyzed. Fifty age-matched healthy volunteers comprised the control group.

Results: A total of 100 asthmatic patients (57 females and 43 males) and 50 controls were participated. hs-CRP in asthmatics was higher than in controls. No significant differences were found in hs-CRP levels in patients with different levels of asthma control based on ACT (≥20, 16-19, ≤15), GINA classification of asthma control (well controlled, partly controlled, uncontrolled) or FEV1.

Conclusion: We found no correlation between degree of systemic inflammation estimated by hs-CRP and other clinical indices of asthma control such as ACT scores, FEV1 and GINA classification of asthma control and even in patients with clinical and spirometric indices of controlled asthma, markers of systemic inflammation were still present.

Citing Articles

Pomegranate extract supplementation improves lung function parameters and IL-35 expression in participants with mild and moderate persistent allergic asthma: A randomized, double-blind, placebo-controlled trial.

Shateri Z, Hosseini S, Abolnezhadian F, Maraghi E, Shoushtari M, Zilaee M Front Nutr. 2022; 9:1026343.

PMID: 36330147 PMC: 9623269. DOI: 10.3389/fnut.2022.1026343.

Asthma phenotype: Clinical, physiological, and biochemical profiles of North Indian patients.

Vennilavan R, Spalgais S, Kumar R Lung India. 2022; 39(2):121-128.

PMID: 35259794 PMC: 9053927. DOI: 10.4103/lungindia.lungindia_334_21.

Soluble CD93 as a Novel Biomarker in Asthma Exacerbation.

Sigari N, Jalili A, Mahdawi L, Ghaderi E, Shilan M Allergy Asthma Immunol Res. 2016; 8(5):461-5.

PMID: 27334785 PMC: 4921701. DOI: 10.4168/aair.2016.8.5.461.

Serum C-reactive protein in asthma and its ability in predicting asthma control, a case-control study.

Monadi M, Firouzjahi A, Hosseini A, Javadian Y, Sharbatdaran M, Heidari B Caspian J Intern Med. 2016; 7(1):37-42.

PMID: 26958331 PMC: 4761121.

References

Nathan R, Sorkness C, Kosinski M, Schatz M, Li J, Marcus P . Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004; 113(1):59-65. DOI: 10.1016/j.jaci.2003.09.008. View

Vigushin D, Pepys M, Hawkins P . Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease. J Clin Invest. 1993; 91(4):1351-7. PMC: 288106. DOI: 10.1172/JCI116336. View

Ko F, Leung T, Hui D, Chu H, Wong G, Wong E . Asthma Control Test correlates well with the treatment decisions made by asthma specialists. Respirology. 2009; 14(4):559-66. DOI: 10.1111/j.1440-1843.2009.01514.x. View

Kony S, Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F . Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax. 2004; 59(10):892-6. PMC: 1746828. DOI: 10.1136/thx.2003.015768. View

Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M . High sensitivity C-reactive protein in asthma. Eur Respir J. 2006; 27(5):908-12. DOI: 10.1183/09031936.06.00114405. View

Jousilahti P, Salomaa V, Hakala K, Rasi V, Vahtera E, Palosuo T . The association of sensitive systemic inflammation markers with bronchial asthma. Ann Allergy Asthma Immunol. 2002; 89(4):381-5. DOI: 10.1016/S1081-1206(10)62039-X. View

Qian F, Zhang Q, Zhou L, Liu H, Huang M, Zhang X . High-sensitivity C-reactive protein: a predicative marker in severe asthma. Respirology. 2008; 13(5):664-9. DOI: 10.1111/j.1440-1843.2008.01314.x. View

Fujita M, Ueki S, Ito W, Chiba T, Takeda M, Saito N . C-reactive protein levels in the serum of asthmatic patients. Ann Allergy Asthma Immunol. 2007; 99(1):48-53. DOI: 10.1016/S1081-1206(10)60620-5. View

Olafsdottir I, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jogi R . C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study. Thorax. 2005; 60(6):451-4. PMC: 1747429. DOI: 10.1136/thx.2004.035774. View

10.

Malerba M, Ragnoli B, Radaeli A, Tantucci C . Usefulness of exhaled nitric oxide and sputum eosinophils in the long-term control of eosinophilic asthma. Chest. 2008; 134(4):733-739. DOI: 10.1378/chest.08-0763. View

11.

Pinto-Plata V, Mullerova H, Toso J, Feudjo-Tepie M, Soriano J, Vessey R . C-reactive protein in patients with COPD, control smokers and non-smokers. Thorax. 2005; 61(1):23-8. PMC: 2080714. DOI: 10.1136/thx.2005.042200. View

12.

Soferman R, Glatstein M, Sivan Y, Weisman Y . HsCRP levels: measurement of airway inflammation in asthmatic children. Pediatr Int. 2008; 50(1):12-6. DOI: 10.1111/j.1442-200X.2007.02517.x. View

13.

Malinovschi A, Pizzimenti S, Sciascia S, Heffler E, Badiu I, Rolla G . Exhaled breath condensate nitrates, but not nitrites or FENO, relate to asthma control. Respir Med. 2011; 105(7):1007-13. DOI: 10.1016/j.rmed.2010.12.016. View

14.

Kwon H, Lee S, Yang M, Lee S, Kim S, Kim D . Correlation between the Korean version of Asthma Control Test and health-related quality of life in adult asthmatics. J Korean Med Sci. 2008; 23(4):621-7. PMC: 2526388. DOI: 10.3346/jkms.2008.23.4.621. View

15.

Pradhan A, Manson J, Rifai N, Buring J, Ridker P . C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001; 286(3):327-34. DOI: 10.1001/jama.286.3.327. View

16.

Melosini L, Dente F, Bacci E, Bartoli M, Cianchetti S, Costa F . Asthma control test (ACT): comparison with clinical, functional, and biological markers of asthma control. J Asthma. 2012; 49(3):317-23. DOI: 10.3109/02770903.2012.661008. View

17.

Anderson G . COPD, asthma and C-reactive protein. Eur Respir J. 2006; 27(5):874-6. DOI: 10.1183/09031936.06.00029306. View

18.

Papakosta D, Latsios D, Manika K, Porpodis K, Kontakioti E, Gioulekas D . Asthma control test is correlated to FEV1 and nitric oxide in Greek asthmatic patients: influence of treatment. J Asthma. 2011; 48(9):901-6. DOI: 10.3109/02770903.2011.611958. View

19.

Senna G, Passalacqua G, Schiappoli M, Lombardi C, Wilcock L . Correlation among FEV, nitric oxide and asthma control test in newly diagnosed asthma. Allergy. 2007; 62(2):207-8. DOI: 10.1111/j.1398-9995.2006.01250.x. View

20.

Khalili B, Boggs P, Shi R, Bahna S . Discrepancy between clinical asthma control assessment tools and fractional exhaled nitric oxide. Ann Allergy Asthma Immunol. 2008; 101(2):124-9. DOI: 10.1016/S1081-1206(10)60199-8. View