» Articles » PMID: 25184908

Complementary Exams in the Diagnosis of American Tegumentary Leishmaniasis

Overview
Specialty Dermatology
Date 2014 Sep 4
PMID 25184908
Citations 30
Authors
Affiliations
Soon will be listed here.
Abstract

The diagnosis of American Tegumentary Leishmaniasis is a difficult but essential task when considering the high toxicity profile of the drugs available. Since the discovery of its etiologic agent, numerous diagnostic tests have been developed. None of the tests available today can be considered as the gold standard, since they do not add enough accuracy for the disease detection. Good epidemiological and clinical knowledge of the disease are fundamental precepts of the dermatology practice and precede the rational use of existing diagnostic tests. In this article we aim, through extensive literature review, to recall fundamental concepts of any diagnostic test. Subsequently, based on this information, we will weave important comments about the characteristics of existing diagnostic tests, including immunological tests such as Montenegro's skin test, serology and detection of parasites by direct examination, culture or histopathology. Finally we will discuss the new technologies and options for the diagnosis of Cutaneous Leishmaniasis. The molecular biology technique is considered a promising tool, promoting the rapid identification of the species involved. We also aim to educate dermatologists about a disease with high morbidity and assist in its difficult recognition.

Citing Articles

High detection rate of parasitic load by qPCR targeting 18S rDNA in blood of patients with active leishmaniasis lesions.

Castanheira G, Amato V, Tuon F, Dantas L, de Carvalho S, Vieira T Eur J Clin Microbiol Infect Dis. 2025; 44(3):717-728.

PMID: 39808375 DOI: 10.1007/s10096-025-05037-4.


Treatment of Refractory Mucosal Leishmaniasis Is Associated with Parasite Overexpression of HSP70 and ATPase and Reduced Host Hydrogen Peroxide Production (Brief Report).

Urdapilleta A, Santos Alfani A, Barroso D, Vinecky F, Amaral Vaz Bandeira S, Andrade A Biomedicines. 2024; 12(10).

PMID: 39457540 PMC: 11504370. DOI: 10.3390/biomedicines12102227.


Cutaneous leishmaniasis on the malar region suggesting squamous cell carcinoma in two elderly patients.

Bueno Filho R, Feres J, Paula N, Barros Junior S, Roselino A An Bras Dermatol. 2024; 99(3):472-475.

PMID: 38403555 PMC: 11074554. DOI: 10.1016/j.abd.2023.06.008.


Automated Identification of Cutaneous Leishmaniasis Lesions Using Deep-Learning-Based Artificial Intelligence.

Leal J, Barroso D, Trindade N, de Miranda V, Gurgel-Goncalves R Biomedicines. 2024; 12(1).

PMID: 38275373 PMC: 10813291. DOI: 10.3390/biomedicines12010012.


Big is not better: Comparing two alpha-Gal-bearing glycotopes in neoglycoproteins as biomarkers for Leishmania (Viannia) braziliensis infection.

Montoya A, Gil E, Vinales I, Estevao I, Taboada P, Torrico M Carbohydr Res. 2024; 536:109015.

PMID: 38198982 PMC: 11366264. DOI: 10.1016/j.carres.2023.109015.


References
1.
Roselino A, Chociay M, Costa R, Machado A, Figueiredo J . L. (L.) chagasi in AIDS and visceral leishmaniasis (kala-azar) co-infection. Rev Inst Med Trop Sao Paulo. 2008; 50(4):251-4. DOI: 10.1590/s0036-46652008000400012. View

2.
Machado P, Rosa M, Costa D, Mignac M, Silva J, Schriefer A . Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response. Trans R Soc Trop Med Hyg. 2011; 105(8):438-44. PMC: 3157292. DOI: 10.1016/j.trstmh.2011.05.002. View

3.
Medeiros A, Silva Jr W, Roselino A . DNA sequencing confirms the involvement of Leishmania (L.) amazonensis in American tegumentary leishmaniasis in the state of São Paulo, Brazil. Clinics (Sao Paulo). 2008; 63(4):451-6. PMC: 2664119. DOI: 10.1590/s1807-59322008000400007. View

4.
Motta A, Lopes M, Ito F, Carlos-Bregni R, de Almeida O, Roselino A . Oral leishmaniasis: a clinicopathological study of 11 cases. Oral Dis. 2007; 13(3):335-40. DOI: 10.1111/j.1601-0825.2006.01296.x. View

5.
Herwaldt B . Leishmaniasis. Lancet. 1999; 354(9185):1191-9. DOI: 10.1016/S0140-6736(98)10178-2. View