Micronutrients and Superoxide Dismutase in Postmenopausal Women with Chronic Periodontitis: a Pilot Interventional Study

Overview

Journal J Periodontal Implant Sci

Specialty Dentistry

Date 2014 Sep 2

PMID 25177523

Citations 2

Authors

Sunita Daiya

Rajinder Kumar Sharma

Shikha Tewari

Satish Chander Narula

Paramjeet Kumar Sehgal

Affiliations

Soon will be listed here.

Abstract

Purpose: The study was aimed at investigating changes in periodontal parameters and superoxide dismutase activity triggered by root surface debridement with and without micronutrient supplementation in postmenopausal women.

Methods: Forty-three postmenopausal chronic periodontitis patients were divided into two groups: group 1 (n=22) were provided periodontal treatment in the form of scaling and root planing (SRP) and group 2 (n=21) patients received SRP along with systemic administration of micronutrient antioxidants. Patients in both groups were subjected to root surface debridement. Group 2 patients also received adjunctive micronutrient antioxidant supplementation. Serum and salivary superoxide dismutase (SOD) activity along with periodontal parameters were recorded at baseline and 3 months after therapy.

Results: Salivary and serum SOD values significantly (P<0.05) improved with periodontal treatment. Improvement in systemic enzymatic antioxidant status along with reduction in gingival inflammation and bleeding on probing (%) sites was significantly greater in group 2 as compared to group 1.

Conclusions: Adjunctive micronutrient supplements reduce periodontal inflammation and improve the status of systemic enzymatic antioxidants in postmenopausal women.

Citing Articles

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Liu X, Yang B, Zhang Y, Guo X, Yang Q, Liu X BMC Oral Health. 2021; 21(1):513.

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Pathways that Regulate ROS Scavenging Enzymes, and Their Role in Defense Against Tissue Destruction in Periodontitis.

Kanzaki H, Wada S, Narimiya T, Yamaguchi Y, Katsumata Y, Itohiya K Front Physiol. 2017; 8:351.

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