Microsporidian Genomes Harbor a Diverse Array of Transposable Elements That Demonstrate an Ancestry of Horizontal Exchange with Metazoans

Overview

Journal Genome Biol Evol

Publisher Oxford University Press

Specialties Biology
Genetics
Molecular Biology

Date 2014 Aug 31

PMID 25172905

Citations 29

Authors

Nicolas Parisot

Adrian Pelin

Cyrielle Gasc

Valerie Polonais

Abdel Belkorchia

Johan Panek

Hicham El Alaoui

David G Biron

Emilie Brasset

Chantal Vaury

Pierre Peyret

Nicolas Corradi

Eric Peyretaillade

Emmanuelle Lerat

Affiliations

Soon will be listed here.

Abstract

Microsporidian genomes are the leading models to understand the streamlining in response to a pathogenic lifestyle; they are gene-poor and often possess small genomes. In this study, we show a feature of microsporidian genomes that contrasts this pattern of genome reduction. Specifically, genome investigations targeted at Anncaliia algerae, a human pathogen with a genome size of 23 Mb, revealed the presence of a hitherto undetected diversity in transposable elements (TEs). A total of 240 TE families per genome were identified, exceeding that found in many free-living fungi, and searches of microsporidian species revealed that these mobile elements represent a significant portion of their coding repertoire. Their phylogenetic analysis revealed that many cases of ancestry involve recent and bidirectional horizontal transfers with metazoans. The abundance and horizontal transfer origin of microsporidian TEs highlight a novel dimension of genome evolution in these intracellular pathogens, demonstrating that factors beyond reduction are at play in their diversification.

Citing Articles

Bioinformatics analysis of the Microsporidia sp. MB genome: a malaria transmission-blocking symbiont of the Anopheles arabiensis mosquito.

Angango L, Herren J, Tastan Bishop O BMC Genomics. 2024; 25(1):1132.

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MicroAnnot: A Dedicated Workflow for Accurate Microsporidian Genome Annotation.

Tournayre J, Polonais V, Wawrzyniak I, Akossi R, Parisot N, Lerat E Int J Mol Sci. 2024; 25(2).

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Contrasting outcomes of genome reduction in mikrocytids and microsporidians.

Zarsky V, Karnkowska A, Boscaro V, Trznadel M, Whelan T, Hiltunen-Thoren M BMC Biol. 2023; 21(1):137.

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The intracellular parasite Anncaliia algerae induces a massive miRNA down-regulation in human cells.

Akossi R, Delbac F, El Alaoui H, Wawrzyniak I, Peyretaillade E Noncoding RNA Res. 2023; 8(3):363-375.

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