Small Molecule Mcl-1 Inhibitors for the Treatment of Cancer

Overview

Journal Pharmacol Ther

Specialty Pharmacology

Date 2014 Aug 31

PMID 25172548

Citations 78

Authors

Johannes Belmar

Stephen W Fesik

Affiliations

Soon will be listed here.

Abstract

The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors.

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