Clinical and Dosimetric Evaluation of RapidArc Versus Standard Sliding Window IMRT in the Treatment of Head and Neck Cancer

Overview

Journal Strahlenther Onkol

Specialties Oncology
Radiology

Date 2014 Aug 30

PMID 25168752

Citations 7

Authors

Stephanie Smet

Maarten Lambrecht

Bianca Vanstraelen

Sandra Nuyts

Affiliations

Soon will be listed here.

Abstract

Background: Several planning studies have already proven the substantial dosimetric advantages of RapidArc (RA) over standard intensity-modulated radiotherapy. We retrospectively compared RapidArc and standard sliding window IMRT (swIMRT) in locally advanced head and neck cancer, looking both at dosimetrics as well as toxicity and outcome.

Methods: CT datasets of 78 patients treated with swIMRT and 79 patients treated with RA were included. To compare the resulting dose distributions, the dose-volume parameters were evaluated for the planning target volumes (PTVs), clinical target volumes (CTVs), and organs at risk (OARs), and the number of MU were calculated. Acute toxicity was assessed by the Common Toxicity Criteria version 3.0.

Results: PTV coverage with the 95% isodose was slightly better for RA. Dose distribution has proven to be significantly more homogenous with RA and led to a reduction of 62% in MU with better OAR sparing. As for toxicity, more grade 3 mucositis and dysphagia was observed for swIMRT, though we observed more grade 3 dermatitis for RA.

Conclusion: In our retrospective analysis, RA had better target coverage and better sparing of the OAR. Overall, the grade of acute toxicity was lower for RA than for swIMRT for the same types of tumor locations, except for the grade of dermatitis.

Citing Articles

Comparison of Volumetric Modulated Arc Therapy (VMAT) and Conventional Intensity-Modulated Radiotherapy (IMRT) for Locally Advanced Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study.

Algouneh A, Schneider K, Huang K, Hussein A, Pan M Cureus. 2024; 16(5):e61022.

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Dosimetric comparison of coplanar and non-coplanar volumetric-modulated arc therapy in head and neck cancer treated with radiotherapy.

Gayen S, Kombathula S, Manna S, Varshney S, Pareek P Radiat Oncol J. 2020; 38(2):138-147.

PMID: 33012157 PMC: 7533406. DOI: 10.3857/roj.2020.00143.

RapidArc vs Conventional IMRT for Head and Neck Cancer Irradiation: Is Faster Necessary Better?.

Mashhour K, Kamaleldin M, Hashem W Asian Pac J Cancer Prev. 2018; 19(1):207-211.

PMID: 29373915 PMC: 5844619. DOI: 10.22034/APJCP.2018.19.1.207.

Multi-isocentric 4π volumetric-modulated arc therapy approach for head and neck cancer.

Subramanian V, Subramani V, Chilukuri S, Kathirvel M, Arun G, Swamy S J Appl Clin Med Phys. 2017; 18(5):293-300.

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Volumetric modulated arc therapy for treatment of solid tumors: current insights.

Macchia G, Deodato F, Cilla S, Cammelli S, Guido A, Ferioli M Onco Targets Ther. 2017; 10:3755-3772.

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