Idiopathic Cerebrospinal Fluid Overproduction: Case-based Review of the Pathophysiological Mechanism Implied in the Cerebrospinal Fluid Production

Overview

Journal Croat Med J

Specialty General Medicine

Date 2014 Aug 29

PMID 25165051

Citations 12

Authors

Gianluca Trevisi

Paolo Frassanito

Concezio Di Rocco

Affiliations

Soon will be listed here.

Abstract

Cerebrospinal fluid (CSF) overproduction results from either CSF infection or choroid plexus hypertrophy or tumor, with only a single idiopathic case described so far. We report a unique case of a male infant with Crouzon syndrome who presented with intracranial hypertension, caused by up to 4-fold increase in CSF daily production. Conditions related to CSF overproduction, namely central nervous system infections and choroid plexus hypertrophy or tumor, were ruled out by repeated magnetic resonance imaging and CSF samples. Medical therapy failed to reduce CSF production and the patient underwent several shunting procedures, cranial expansion, and endoscopic coagulation of the choroid plexus. This article thoroughly reviews pertinent literature on CSF production mechanisms and possible therapeutic implications.

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