Vitamin D and Its Relationship with Obesity and Muscle

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2014 Aug 28

PMID 25161666

Citations 39

Authors

Cristiana Cipriani

Jessica Pepe

Sara Piemonte

Luciano Colangelo

Mirella Cilli

Salvatore Minisola

Affiliations

Soon will be listed here.

Abstract

The skin synthesis of vitamin D represents the first step of a metabolic pathway whose features have been extensively studied and clarified in the last decades. In particular, the production of active and inactive forms of the hormone and the actions of the corresponding enzymes have offered new insights into the knowledge of vitamin D metabolism. Additionally, the description of the different organs and tissues expressing the vitamin D receptor and its possible functions, as well as its genetic determinants, have allowed focusing on the interrelationship between vitamin D and many physiological and pathological functions. In this context, many studies reported the association between vitamin D and adipose tissue metabolism, as well as the possible role of the hormone in obesity, weight, and fat mass distribution. Finally, many reports focused on the vitamin D-related effects on skeletal muscle, particularly on the mechanisms by which vitamin D could directly affect muscle mass and strength. This paper is mainly aimed to review vitamin D metabolism and its relationship with obesity and skeletal muscle function.

Citing Articles

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Serum vitamin D and obesity among US adolescents, NHANES 2011-2018.

Chen Z, Qiu X, Wang Q, Wu J, Li M, Niu W Front Pediatr. 2024; 12:1334139.

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The correlation of obesity status with serum 25-hydroxyvitamin D in US Asian adults: NHANES 2011-2018.

Qiu L, Ren Y, Li J, Li M, Li W, Qin L PLoS One. 2024; 19(4):e0301327.

PMID: 38626143 PMC: 11020701. DOI: 10.1371/journal.pone.0301327.

High-fat diet effects on contractile performance of isolated mouse soleus and extensor digitorum longus when supplemented with high dose vitamin D.

Shelley S, James R, Eustace S, Eyre E, Tallis J Exp Physiol. 2023; 109(2):283-301.

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Vitamin D supplementation in a post-pandemic era: A narrative review.

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