Cracking the ANP32 Whips: Important Functions, Unequal Requirement, and Hints at Disease Implications

Overview

Journal Bioessays

Publisher Wiley

Specialties Biology
Cell Biology
Molecular Biology

Date 2014 Aug 27

PMID 25156960

Citations 48

Authors

Patrick T Reilly

Yun Yu

Ali Hamiche

Lishun Wang

Affiliations

Soon will be listed here.

Abstract

The acidic (leucine-rich) nuclear phosphoprotein 32 kDa (ANP32) family is composed of small, evolutionarily conserved proteins characterized by an N-terminal leucine-rich repeat domain and a C-terminal low-complexity acidic region. The mammalian family members (ANP32A, ANP32B, and ANP32E) are ascribed physiologically diverse functions including chromatin modification and remodelling, apoptotic caspase modulation, protein phosphatase inhibition, as well as regulation of intracellular transport. In addition to reviewing the widespread literature on the topic, we present a concept of the ANP32s as having a whip-like structure. We also present hypotheses that ANP32C and other intronless sequences should not currently be considered bona fide family members, that their disparate necessity in development may be due to compensatory mechanisms, that their contrasting roles in cancer are likely context-dependent, along with an underlying hypothesis that ANP32s represent an important node of physiological regulation by virtue of their diverse biochemical activities.

Citing Articles

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Avian ANP32A incorporated in avian influenza A virions promotes interspecies transmission by priming early viral replication in mammals.

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References

Yan N, Cherepanov P, Daigle J, Engelman A, Lieberman J . The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 2009; 5(3):e1000327. PMC: 2644782. DOI: 10.1371/journal.ppat.1000327. View

Higashino F, Aoyagi M, Takahashi A, Ishino M, Taoka M, Isobe T . Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism. J Cell Biol. 2005; 170(1):15-20. PMC: 2171388. DOI: 10.1083/jcb.200405112. View

Reilly P, Afzal S, Wakeham A, Haight J, You-Ten A, Zaugg K . Generation and characterization of the Anp32e-deficient mouse. PLoS One. 2010; 5(10):e13597. PMC: 2964292. DOI: 10.1371/journal.pone.0013597. View

Schneider R, Bannister A, Weise C, Kouzarides T . Direct binding of INHAT to H3 tails disrupted by modifications. J Biol Chem. 2004; 279(23):23859-62. DOI: 10.1074/jbc.C400151200. View

Schafer Z, Parrish A, Wright K, Margolis S, Marks J, Deshmukh M . Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. Cancer Res. 2006; 66(4):2210-8. DOI: 10.1158/0008-5472.CAN-05-3923. View

Tochio N, Umehara T, Munemasa Y, Suzuki T, Sato S, Tsuda K . Solution structure of histone chaperone ANP32B: interaction with core histones H3-H4 through its acidic concave domain. J Mol Biol. 2010; 401(1):97-114. DOI: 10.1016/j.jmb.2010.06.005. View

Nekrasov M, Amrichova J, Parker B, Soboleva T, Jack C, Williams R . Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics. Nat Struct Mol Biol. 2012; 19(11):1076-83. DOI: 10.1038/nsmb.2424. View

Costanzo R, Vila-Ortiz G, Perandones C, Carminatti H, Matilla A, Radrizzani M . Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis. Eur J Neurosci. 2006; 23(2):309-24. DOI: 10.1111/j.1460-9568.2005.04555.x. View

Li M, Makkinje A, Damuni Z . Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A. Biochemistry. 1996; 35(22):6998-7002. DOI: 10.1021/bi960581y. View

10.

Hoffarth S, Zitzer A, Wiewrodt R, Hahnel P, Beyer V, Kreft A . pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer. Cell Death Differ. 2007; 15(1):161-70. DOI: 10.1038/sj.cdd.4402256. View

11.

Matsuoka K, Taoka M, Satozawa N, Nakayama H, Ichimura T, Takahashi N . A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons. Proc Natl Acad Sci U S A. 1994; 91(21):9670-4. PMC: 44878. DOI: 10.1073/pnas.91.21.9670. View

12.

Ulitzur N, Humbert M, Pfeffer S . Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules. Proc Natl Acad Sci U S A. 1997; 94(10):5084-9. PMC: 24635. DOI: 10.1073/pnas.94.10.5084. View

13.

Tsukamoto Y, Uchida T, Karnan S, Noguchi T, Nguyen L, Tanigawa M . Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer. J Pathol. 2008; 216(4):471-82. DOI: 10.1002/path.2424. View

14.

Radrizzani M, Cafferata E, Di Tella M, Perandones C, Pivetta O, Carminatti H . Differential expression of CPD1 during postnatal development in the mouse cerebellum. Brain Res. 2001; 907(1-2):162-74. DOI: 10.1016/s0006-8993(01)02351-4. View

15.

Ouellet V, Le Page C, Guyot M, Lussier C, Tonin P, Provencher D . SET complex in serous epithelial ovarian cancer. Int J Cancer. 2006; 119(9):2119-26. DOI: 10.1002/ijc.22054. View

16.

Callebaut C, Blanco J, Benkirane N, Krust B, Jacotot E, Guichard G . Identification of V3 loop-binding proteins as potential receptors implicated in the binding of HIV particles to CD4(+) cells. J Biol Chem. 1998; 273(34):21988-97. DOI: 10.1074/jbc.273.34.21988. View

17.

Seo S, McNamara P, Heo S, Turner A, Lane W, Chakravarti D . Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell. 2001; 104(1):119-30. DOI: 10.1016/s0092-8674(01)00196-9. View

18.

Chakravarti D, Hong R . SET-ting the stage for life and death. Cell. 2003; 112(5):589-91. DOI: 10.1016/s0092-8674(03)00151-x. View

19.

Pan W, da Graca L, Shao Y, Yin Q, Wu H, Jiang X . PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. J Biol Chem. 2009; 284(11):6946-54. PMC: 2652289. DOI: 10.1074/jbc.M805801200. View

20.

Christensen D, Chen Y, Oddo J, Matta K, Neil J, Davis E . SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. Blood. 2011; 118(15):4150-8. PMC: 3204732. DOI: 10.1182/blood-2011-04-351072. View