Metabolic Precursor Regulation of Aflatoxin Formation in Toxigenic and Non-toxigenic Strains of Aspergillus Flavus

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 1989 Sep 1

PMID 2515437

Citations 5

Authors

L S Lee

Affiliations

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Abstract

Non-aflatoxin-producing isolates of Aspergillus flavus from nature and isolates of A. flavus that had lost their toxigenic trait following laboratory transfer were compared biochemically. After the addition of aflatoxin B1 precursors sterigmatocystin or O-methylsterigmatocystin to whole cell cultures, the non-toxin producing isolates from nature remained non-toxigenic while toxigenicity was restored in the non-toxigenic laboratory strains. Results imply a lack of enzymes needed for biochemical conversions of precursors to aflatoxin B1 in natural non-producers and suppression of these enzymes in the non-producing laboratory strains.

Citing Articles

Synthesis of sterigmatocystin derivatives and their biotransformation to aflatoxins by a blocked mutant of Aspergillus parasiticus.

Gengan R, Chuturgoon A, Mulholland D, Dutton M Mycopathologia. 1999; 144(2):115-22.

PMID: 10481291 DOI: 10.1023/a:1007064304292.

Characterization of experimentally induced, nonaflatoxigenic variant strains of Aspergillus parasiticus.

Kale S, Cary J, Bhatnagar D, Bennett J Appl Environ Microbiol. 1996; 62(9):3399-404.

PMID: 8795232 PMC: 168138. DOI: 10.1128/aem.62.9.3399-3404.1996.

Variability among atoxigenic Aspergillus flavus strains in ability to prevent aflatoxin contamination and production of aflatoxin biosynthetic pathway enzymes.

Cotty P, Bhatnagar D Appl Environ Microbiol. 1994; 60(7):2248-51.

PMID: 8074506 PMC: 201639. DOI: 10.1128/aem.60.7.2248-2251.1994.

Transformation of sterigmatocystin and O-methylsterigmatocystin by aflatoxigenic and nonaflatoxigenic field isolates of the Aspergillus flavus group.

Pro M, Moreno M, Suarez G Mycopathologia. 1991; 116(2):71-5.

PMID: 1780000 DOI: 10.1007/BF00436367.

Variants of Aspergillus alutaceus var. alutaceus (formerly Aspergillus ochraceus) with altered ochratoxin A production.

Chelack W, Borsa J, Szekely J, Marquardt R, Frohlich A Appl Environ Microbiol. 1991; 57(9):2487-91.

PMID: 1768122 PMC: 183607. DOI: 10.1128/aem.57.9.2487-2491.1991.

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