The Importance of Monocytes and Macrophages in HIV Pathogenesis, Treatment, and Cure

Overview

Journal AIDS

Specialty Infectious Diseases

Date 2014 Aug 22

PMID 25144219

Citations 111

Authors

Jennifer H Campbell

Anna C Hearps

Genevieve E Martin

Kenneth C Williams

Suzanne M Crowe

Affiliations

Soon will be listed here.

Abstract

Monocytes and macrophages play critical roles in HIV transmission, viral spread early in infection, and as a reservoir of virus throughout infection. There has been a recent resurgence of interest in the biology of monocyte subsets and macrophages and their role in HIV pathogenesis, partly fuelled by efforts to understand difficulties in achieving HIV eradication. This article examines the importance of monocyte subsets and tissue macrophages in HIV pathogenesis. Additionally, we will review the role of monocytes and macrophages in the development of serious non-AIDS events including cardiovascular disease and neurocognitive impairment, their significance in viral persistence, and how these cells represent an important obstacle to achieving HIV eradication.

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References

Peressin M, Proust A, Schmidt S, Su B, Lambotin M, Biedma M . Efficient transfer of HIV-1 in trans and in cis from Langerhans dendritic cells and macrophages to autologous T lymphocytes. AIDS. 2014; 28(5):667-77. DOI: 10.1097/QAD.0000000000000193. View

Wang X, Ye L, Hou W, Zhou Y, Wang Y, Metzger D . Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection. Blood. 2008; 113(3):671-4. PMC: 2628373. DOI: 10.1182/blood-2008-09-175000. View

Baker J, Hullsiek K, Singh A, Wilson E, Henry K, Lichtenstein K . Immunologic predictors of coronary artery calcium progression in a contemporary HIV cohort. AIDS. 2013; 28(6):831-40. PMC: 4199584. DOI: 10.1097/QAD.0000000000000145. View

Berger G, Durand S, Fargier G, Nguyen X, Cordeil S, Bouaziz S . APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells. PLoS Pathog. 2011; 7(9):e1002221. PMC: 3178557. DOI: 10.1371/journal.ppat.1002221. View

Williams D, Eugenin E, Calderon T, Berman J . Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis. J Leukoc Biol. 2012; 91(3):401-15. PMC: 3289493. DOI: 10.1189/jlb.0811394. View

Migueles S, Connors M . Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV. JAMA. 2010; 304(2):194-201. DOI: 10.1001/jama.2010.925. View

Friis-Moller N, Reiss P, Sabin C, Weber R, Monforte A, El-Sadr W . Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med. 2007; 356(17):1723-35. DOI: 10.1056/NEJMoa062744. View

Segal L, Methe B, Nolan A, Hoshino Y, Rom W, Dawson R . HIV-1 and bacterial pneumonia in the era of antiretroviral therapy. Proc Am Thorac Soc. 2011; 8(3):282-7. PMC: 3132786. DOI: 10.1513/pats.201006-044WR. View

Kuller L, Tracy R, Belloso W, De Wit S, Drummond F, Lane H . Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 2008; 5(10):e203. PMC: 2570418. DOI: 10.1371/journal.pmed.0050203. View

10.

Hsu D, Sereti I, Ananworanich J . Serious Non-AIDS events: Immunopathogenesis and interventional strategies. AIDS Res Ther. 2013; 10(1):29. PMC: 3874658. DOI: 10.1186/1742-6405-10-29. View

11.

Gendelman H, Orenstein J, Martin M, Ferrua C, Mitra R, Phipps T . Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med. 1988; 167(4):1428-41. PMC: 2188914. DOI: 10.1084/jem.167.4.1428. View

12.

Jurriaans S, Dekker J, de Ronde A . HIV-1 viral DNA load in peripheral blood mononuclear cells from seroconverters and long-term infected individuals. AIDS. 1992; 6(7):635-41. DOI: 10.1097/00002030-199207000-00004. View

13.

Desquilbet L, Jacobson L, Fried L, Phair J, Jamieson B, Holloway M . HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007; 62(11):1279-86. DOI: 10.1093/gerona/62.11.1279. View

14.

Gelman B, Lisinicchia J, Morgello S, Masliah E, Commins D, Achim C . Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort. J Acquir Immune Defic Syndr. 2012; 62(5):487-95. PMC: 3664102. DOI: 10.1097/QAI.0b013e31827f1bdb. View

15.

Heaton R, Franklin D, Ellis R, McCutchan J, Letendre S, LeBlanc S . HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2010; 17(1):3-16. PMC: 3032197. DOI: 10.1007/s13365-010-0006-1. View

16.

Hutter G, Nowak D, Mossner M, Ganepola S, Mussig A, Allers K . Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009; 360(7):692-8. DOI: 10.1056/NEJMoa0802905. View

17.

Buzon M, Codoner F, Frost S, Pou C, Puertas M, Massanella M . Deep molecular characterization of HIV-1 dynamics under suppressive HAART. PLoS Pathog. 2011; 7(10):e1002314. PMC: 3203183. DOI: 10.1371/journal.ppat.1002314. View

18.

Katlama C, Deeks S, Autran B, Martinez-Picado J, van Lunzen J, Rouzioux C . Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet. 2013; 381(9883):2109-17. PMC: 3815451. DOI: 10.1016/S0140-6736(13)60104-X. View

19.

Valcour V, Shiramizu B, Shikuma C . HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications. J Leukoc Biol. 2010; 87(4):621-6. PMC: 2858306. DOI: 10.1189/jlb.0809571. View

20.

Erlandson K, ORiordan M, Labbato D, McComsey G . Relationships between inflammation, immune activation, and bone health among HIV-infected adults on stable antiretroviral therapy. J Acquir Immune Defic Syndr. 2014; 65(3):290-8. PMC: 3927157. DOI: 10.1097/QAI.0000000000000005. View