» Articles » PMID: 25143860

The Role of Molecular Imaging in Diagnosis of Deep Vein Thrombosis

Overview
Date 2014 Aug 22
PMID 25143860
Citations 24
Authors
Affiliations
Soon will be listed here.
Abstract

Venous thromboembolism (VTE) mostly presenting as deep venous thrombosis (DVT) and pulmonary embolism (PE) affects up to 600,000 individuals in United States each year. Clinical symptoms of VTE are nonspecific and sometimes misleading. Additionally, side effects of available treatment plans for DVT are significant. Therefore, medical imaging plays a crucial role in proper diagnosis and avoidance from over/under diagnosis, which exposes the patient to risk. In addition to conventional structural imaging modalities, such as ultrasonography and computed tomography, molecular imaging with different tracers have been studied for diagnosis of DVT. In this review we will discuss currently available and newly evolving targets and tracers for detection of DVT using molecular imaging methods.

Citing Articles

Bio-distribution study of Tc-99m HMPAO labeled platelet in healthy volunteer.

Parvizi M, Abbasi M, Ahmadzadehfar H, Tafakhori A, Naseri M, Khalaj A Asia Ocean J Nucl Med Biol. 2024; 12(2):142-148.

PMID: 39050242 PMC: 11263780. DOI: 10.22038/AOJNMB.2024.71620.1525.


The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19.

Griffin M, Werner T, Alavi A, Revheim M Eur Phys J Plus. 2023; 138(3):283.

PMID: 37008755 PMC: 10040919. DOI: 10.1140/epjp/s13360-023-03797-6.


Molecular Imaging and Non-molecular Imaging of Atherosclerotic Plaque Thrombosis.

Guo B, Li Z, Tu P, Tang H, Tu Y Front Cardiovasc Med. 2021; 8:692915.

PMID: 34291095 PMC: 8286992. DOI: 10.3389/fcvm.2021.692915.


FDG-PET/CT of COVID-19 and Other Lung Infections.

Eibschutz L, Rabiee B, Asadollahi S, Gupta A, Assadi M, Alavi A Semin Nucl Med. 2021; 52(1):61-70.

PMID: 34246449 PMC: 8216878. DOI: 10.1053/j.semnuclmed.2021.06.017.


Correlation between presence of lower limb varicose veins and deep venous thrombosis.

Cacione D, Do Carmo Novaes F, Silva J J Vasc Bras. 2021; 19:e20200081.

PMID: 34178081 PMC: 8202180. DOI: 10.1590/1677-5449.200081.


References
1.
BAUTOVICH G, Angelides S, Lee F, Greenough R, Bundesen P, Murray P . Detection of deep venous thrombi and pulmonary embolus with technetium-99m-DD-3B6/22 anti-fibrin monoclonal antibody Fab' fragment. J Nucl Med. 1994; 35(2):195-202. View

2.
Hess S, Madsen P, Iversen E, Frifelt J, Hoilund-Carlsen P, Alavi A . Efficacy of FDG PET/CT imaging for venous thromboembolic disorders: preliminary results from a prospective, observational pilot study. Clin Nucl Med. 2014; 40(1):e23-6. DOI: 10.1097/RLU.0000000000000453. View

3.
Luckers A, Luth W, Teule G, Huijgens P, Heidendal G . Diagnosis of deep venous thrombosis with 99mTc plasmin using the gamma camera. Eur J Nucl Med. 1984; 9(6):282-3. DOI: 10.1007/BF00803251. View

4.
Spyropoulos A, Hurley J, Ciesla G, de Lissovoy G . Management of acute proximal deep vein thrombosis: pharmacoeconomic evaluation of outpatient treatment with enoxaparin vs inpatient treatment with unfractionated heparin. Chest. 2002; 122(1):108-14. DOI: 10.1378/chest.122.1.108. View

5.
Alavi A, Gupta N, Palevsky H, Kelley M, Jatlow A, Byar A . Detection of thrombophlebitis with 111In-labeled anti-fibrin antibody: preliminary results. Cancer Res. 1990; 50(3 Suppl):958s-961s. View