Changes in Brain Mitochondrial Bioenergetics in Protein-deficient Rats

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1989 Dec 1

PMID 2513864

Citations 1

Authors

O O Olorunsogo

Affiliations

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Abstract

An assessment of mitochondrial bioenergetics in protein-malnourished rats indicates that there is a reduction of brain mitochondrial metabolism in protein malnutrition. Specifically, mitochondria of protein-malnourished offspring of malnourished rats exhibit (i) an enhancement of state 4 respiration, (ii) a reduction of ADP-stimulated state 3 respiration, (iii) a decrease in ADP:O ratios, (iv) reductions of FCCP-induced ATPase action and in the rates of proton and calcium ion translocation, and (v) diminished activities of redox enzymes. In general, these changes are less pronounced in malnourished weanling rats born of healthy dams. Although the exact molecular mechanism of these defects is not yet known, the alterations are definitely caused by diet-induced changes in the structure and integrity of inner mitochondrial membrane components.

Citing Articles

Maternal Protein Restriction in Two Successive Generations Impairs Mitochondrial Electron Coupling in the Progeny's Brainstem of Rats From Both Sexes.

Santana D, Ferreira D, Braz G, Sousa S, Silva T, Gomes D Front Neurosci. 2019; 13:203.

PMID: 30930735 PMC: 6427765. DOI: 10.3389/fnins.2019.00203.

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