Management of Infantile Hemangiomas: Current Trends

Overview

Journal J Cutan Aesthet Surg

Date 2014 Aug 20

PMID 25136206

Citations 22

Authors

Gomathy Sethuraman

Vamsi K Yenamandra

Vishal Gupta

Affiliations

Soon will be listed here.

Abstract

Infantile hemangiomas (IH) are common vascular tumours. IH have a characteristic natural course. They proliferate rapidly during the early infantile period followed by a period of gradual regression over several years. Most of the uncomplicated IH undergo spontaneous involution, with a small proportion of cases requiring intervention. These are children with IH in life-threatening locations, local complications like haemorrhage, ulceration and necrosis and functional or cosmetic disfigurements. Systemic corticosteroids have been the first line of treatment for many years. Recently, non-selective beta-blockers, such as oral propranalol and topical timolol, have emerged as promising and safer therapies. Other treatment options include interferon α and vincristine which are reserved for life-threatening haemangiomas that are unresponsive to conventional therapy. This review mainly focuses on the current trends and evidence-based approach in the management of IH.

Citing Articles

Infantile Hemangioma in Infancy: A Case Study on the Natural Course and Therapeutic Management.

Gullabzada M, Brito Y, Gonzalez A, Zena D, Jabri M Cureus. 2024; 16(6):e63156.

PMID: 39070329 PMC: 11272419. DOI: 10.7759/cureus.63156.

Rare complication - skin atrophy - after systemic conservative therapy of infantile hemangioma.

Chakhunashvili K, Kvirkvelia E, Todua N, Chakhunashvili D BMC Pediatr. 2024; 24(1):138.

PMID: 38395819 PMC: 10885403. DOI: 10.1186/s12887-024-04638-w.

Overview of the Head and Neck Hemangiomas: a 5-year Retrospective Study.

Filaj V, Kola I, Gjonaj F Mater Sociomed. 2023; 35(3):244-247.

PMID: 37795158 PMC: 10545920. DOI: 10.5455/msm.2023.35.244-247.

Infantile Hemangioma of the Upper Lip: Report of a Rare Case With a Brief Review of Literature.

Hasan S, Khan A, Banerjee A, Ramalingam K Cureus. 2023; 15(7):e42556.

PMID: 37637601 PMC: 10460138. DOI: 10.7759/cureus.42556.

Anesthetic and Airway Management in a Case of Surgical Excision of Recurrent Buccal Hemangioma.

Mankhair Jr S, Jadhav J, Chakole V, Singam A, Verma N Cureus. 2023; 15(6):e39951.

PMID: 37416048 PMC: 10319597. DOI: 10.7759/cureus.39951.

References

Causse S, Aubert H, Saint-Jean M, Puzenat E, Bursztejn A, Eschard C . Propranolol-resistant infantile haemangiomas. Br J Dermatol. 2013; 169(1):125-9. DOI: 10.1111/bjd.12417. View

Kunzi-Rapp K . Topical propranolol therapy for infantile hemangiomas. Pediatr Dermatol. 2011; 29(2):154-9. DOI: 10.1111/j.1525-1470.2011.01615.x. View

Garzon M, Lucky A, Hawrot A, Frieden I . Ultrapotent topical corticosteroid treatment of hemangiomas of infancy. J Am Acad Dermatol. 2005; 52(2):281-6. DOI: 10.1016/j.jaad.2004.09.004. View

Marqueling A, Oza V, Frieden I, Puttgen K . Propranolol and infantile hemangiomas four years later: a systematic review. Pediatr Dermatol. 2013; 30(2):182-91. DOI: 10.1111/pde.12089. View

Bertrand J, McCuaig C, Dubois J, Hatami A, Ondrejchak S, Powell J . Propranolol versus prednisone in the treatment of infantile hemangiomas: a retrospective comparative study. Pediatr Dermatol. 2011; 28(6):649-654. DOI: 10.1111/j.1525-1470.2011.01551.x. View

Malik M, Menon P, Rao K, Samujh R . Effect of propranolol vs prednisolone vs propranolol with prednisolone in the management of infantile hemangioma: a randomized controlled study. J Pediatr Surg. 2013; 48(12):2453-9. DOI: 10.1016/j.jpedsurg.2013.08.020. View

Burrows P, Robertson R, Mulliken J, Beardsley D, Chaloupka J, Ezekowitz R . Cerebral vasculopathy and neurologic sequelae in infants with cervicofacial hemangioma: report of eight patients. Radiology. 1998; 207(3):601-7. DOI: 10.1148/radiology.207.3.9609880. View

Li J, Chen X, Zhao S, Hu X, Chen C, Ouyang F . Demographic and clinical characteristics and risk factors for infantile hemangioma: a Chinese case-control study. Arch Dermatol. 2011; 147(9):1049-56. DOI: 10.1001/archdermatol.2011.122. View

Metry D, Hawrot A, Altman C, Frieden I . Association of solitary, segmental hemangiomas of the skin with visceral hemangiomatosis. Arch Dermatol. 2004; 140(5):591-6. DOI: 10.1001/archderm.140.5.591. View

10.

Barlow R, Walker N, Markey A . Treatment of proliferative haemangiomas with the 585 nm pulsed dye laser. Br J Dermatol. 1996; 134(4):700-4. View

11.

Miller T, Frieden I . Hemangiomas: new insights and classification. Pediatr Ann. 2005; 34(3):179-87. DOI: 10.3928/0090-4481-20050301-07. View

12.

Rizzo C, Brightman L, Chapas A, Hale E, Cantatore-Francis J, Bernstein L . Outcomes of childhood hemangiomas treated with the pulsed-dye laser with dynamic cooling: a retrospective chart analysis. Dermatol Surg. 2009; 35(12):1947-54. DOI: 10.1111/j.1524-4725.2009.01356.x. View

13.

Drolet B, Dohil M, Golomb M, Wells R, Murowski L, Tamburro J . Early stroke and cerebral vasculopathy in children with facial hemangiomas and PHACE association. Pediatrics. 2006; 117(3):959-64. DOI: 10.1542/peds.2005-1683. View

14.

Saafan A, Salah M . Using pulsed dual-wavelength 595 and 1064 nm is more effective in the management of hemangiomas. J Drugs Dermatol. 2010; 9(4):310-4. View

15.

Lomenick J, Reifschneider K, Lucky A, Adams D, Azizkhan R, Woo J . Prevalence of adrenal insufficiency following systemic glucocorticoid therapy in infants with hemangiomas. Arch Dermatol. 2009; 145(3):262-6. DOI: 10.1001/archdermatol.2008.572. View

16.

Mhanna A, Franklin W, Mancini A . Hepatic infantile hemangiomas treated with oral propranolol--a case series. Pediatr Dermatol. 2011; 28(1):39-45. DOI: 10.1111/j.1525-1470.2010.01355.x. View

17.

Calvo M, Garcia-Millan C, Villegas C, Fueyo-Casado A, Buron I . Topical timolol for infantile hemangioma of the eyelid. Int J Dermatol. 2012; 52(5):603-4. DOI: 10.1111/j.1365-4632.2011.05290.x. View

18.

Bennett M, Fleischer Jr A, Chamlin S, Frieden I . Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. Arch Dermatol. 2001; 137(9):1208-13. DOI: 10.1001/archderm.137.9.1208. View

19.

Talaat A, Elbasiouny M, Elgendy D, Elwakil T . Propranolol treatment of infantile hemangioma: clinical and radiologic evaluations. J Pediatr Surg. 2012; 47(4):707-14. DOI: 10.1016/j.jpedsurg.2011.10.058. View

20.

Batta K, Goodyear H, Moss C, Williams H, Hiller L, Waters R . Randomised controlled study of early pulsed dye laser treatment of uncomplicated childhood haemangiomas: results of a 1-year analysis. Lancet. 2002; 360(9332):521-7. DOI: 10.1016/S0140-6736(02)09741-6. View