IL-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-versus-host Disease

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2014 Aug 20

PMID 25136146

Citations 2

Authors

Renata Goncalves Resende

Jeane de Fatima Correia-Silva

Tarcilia Aparecida Silva

Ulisses Eliezer Salomao

Luciano Marques-Silva

Erica Leandro Marciano Vieira

Walderez Ornelas Dutra

Ricardo Santiago Gomez

Affiliations

Soon will be listed here.

Abstract

Although interleukin-17 (IL-17) is a recently discovered cytokine associated with several autoimmune diseases, its role in the pathogenesis of chronic graft-versus-host disease (cGVHD) was not established yet. The objective of this study was to investigate the association of IL17A and IL17F genes polymorphisms and IL-17A and IL-17F levels with cGVHD. IL-17A expression was also investigated in CD4(+) T cells of patients with systemic cGVHD. For Part I of the study, fifty-eight allo-HSCT recipients and donors were prospectively studied. Blood samples were obtained to determine IL17A and IL17F genes polymorphisms. Cytokines levels in blood and saliva were assessed by ELISA at days +35 and +100 after HSCT. In Part II, for the immunophenotypic evaluation, eight patients with systemic cGVHD were selected and the expression of IL-17A was evaluated. We found association between recipient AA genotype with systemic cGVHD. No association was observed between IL-17A levels and cGVHD. Lower IL-17A levels in the blood were associated with AA genotype. In flow cytometry analysis, decreased expression of IL-17A was observed in patients with cGVHD after stimulation. In conclusion, IL-17A may have an important role in the development of systemic cGVHD.

Citing Articles

Review of Genetic Variation as a Predictive Biomarker for Chronic Graft-Versus-Host-Disease After Allogeneic Stem Cell Transplantation.

Partanen J, Hyvarinen K, Bickeboller H, Bogunia-Kubik K, Crossland R, Ivanova M Front Immunol. 2020; 11:575492.

PMID: 33193367 PMC: 7604383. DOI: 10.3389/fimmu.2020.575492.

Correlation between acute myeloid leukemia and IL-17A, IL-17F, and IL-23R gene polymorphism.

Zhu B, Zhang J, Wang X, Chen J, Li C Int J Clin Exp Pathol. 2015; 8(5):5739-43.

PMID: 26191290 PMC: 4503161.

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