Can Vitamin D Status Be Assessed by Serum 25OHD in Children?

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2014 Aug 20

PMID 25135619

Citations 7

Authors

Maria Agustina Alonso

Zamir Francisco Pallavicini

Julian Rodriguez

Noelia Avello

Pablo Martinez-Camblor

Fernando Santos

Affiliations

Soon will be listed here.

Abstract

Background: To examine the relationship of serum 25-hydroxyvitamin D (25OHD) concentrations with serum parathyroid hormone (PTH) levels, body mass index (BMI), and environmental factors in a population of Caucasian children living at latitude 43°N.

Methods: Cross-sectional study on 288 children aged 1 month to 13 years who presented to a pediatric emergency unit during a 21-month period.

Results: Mean (SD) serum 25OHD concentrations were 40.6 (17.6), 30.9 (12.0), and 26.4 (9.9) ng/ml (1 ng/ml = 2.5 nmol/l), in children aged 0-1, 2-5, and ≥ 6 years, respectively. Serum PTH levels were 26.6 (13.6), 24.3 (11.9), and 32.7 (12.1) pg/ml in the same groups. Infants had 25OHD concentrations significantly higher. PTH levels were significantly higher in children aged ≥ 6 years. There was no significant correlation between serum 25OHD and PTH concentrations. Totals of 15.6 % and 2.1 % of children had 25OHD values less than 20 and 10 ng/ml, respectively, but none had elevated serum PTH or clinical manifestations related with vitamin D deficiency. Age (inverse correlation) and season (higher values in summer), but not BMI, sex, and time spent outdoors, influenced serum 25OHD concentrations.

Conclusions: Our results raise doubt on the assumption of only a serum 25OHD threshold as indicative of vitamin D deficiency in children.

Citing Articles

Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta-analysis.

Cariolou M, Cupp M, Evangelou E, Tzoulaki I, Berlanga-Taylor A BMJ Open. 2019; 9(5):e027666.

PMID: 31122993 PMC: 6538078. DOI: 10.1136/bmjopen-2018-027666.

Marker of vitamin D status in healthy children: Free or total 25-hydroxyvitamin D?.

Mantecon L, Alonso M, Moya V, Andres A, Avello N, Martinez-Morillo E PLoS One. 2018; 13(8):e0202237.

PMID: 30138329 PMC: 6107142. DOI: 10.1371/journal.pone.0202237.

The roles of vitamin D and dietary calcium in nutritional rickets.

Thandrayen K, Pettifor J Bone Rep. 2018; 8:81-89.

PMID: 29955625 PMC: 6019962. DOI: 10.1016/j.bonr.2018.01.005.

Do all infants need vitamin D supplementation?.

Almeida A, de Paula F, Monteiro J, Nogueira-de-Almeida C, Ciampo L, Aragon D PLoS One. 2018; 13(4):e0195368.

PMID: 29649273 PMC: 5896946. DOI: 10.1371/journal.pone.0195368.

A systematic review of vitamin D status in southern European countries.

Manios Y, Moschonis G, Lambrinou C, Tsoutsoulopoulou K, Binou P, Karachaliou A Eur J Nutr. 2017; 57(6):2001-2036.

PMID: 29090332 DOI: 10.1007/s00394-017-1564-2.

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