Review to Better Understand the Macroscopic Subtypes and Histogenesis of Intrahepatic Cholangiocarcinoma

Overview

Journal World J Gastrointest Pathophysiol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2014 Aug 19

PMID 25133021

Citations 9

Authors

Yuichi Sanada

Yujo Kawashita

Satomi Okada

Takashi Azuma

Shigetoshi Matsuo

Affiliations

Soon will be listed here.

Abstract

Intrahepatic cholangiocarcinoma is macroscopically classified into three subtypes, mass-forming-type, periductal infiltrating-type, and intraductal growth-type. Each subtype should be preoperatively differentiated to perform the valid surgical resection. Recent researches have revealed the clinical, radiologic, pathobiological characteristics of each subtype. We reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma (ICC), focusing especially on the macroscopic subtypes and stem cell features to better understand the pathophysiology of ICC and to establish the valid therapeutic strategy.

Citing Articles

Vascular Resection for Intrahepatic Cholangiocarcinoma: Current Considerations.

Alikhanov R, Dudareva A, Trigo M, Serrablo A J Clin Med. 2021; 10(17).

PMID: 34501276 PMC: 8432051. DOI: 10.3390/jcm10173829.

Apparent diffusion coefficient value of mass-forming intrahepatic cholangiocarcinoma: a potential imaging biomarker for prediction of lymph node metastasis.

Zhou Y, Zhou G, Gao X, Xu C, Wang X, Xu P Abdom Radiol (NY). 2020; 45(10):3109-3118.

PMID: 32107582 DOI: 10.1007/s00261-020-02458-x.

Macroscopic types of intrahepatic cholangiocarcinoma and the eighth edition of AJCC/UICC TNM staging system.

Meng Z, Pan W, Hong H, Chen J, Chen Y Oncotarget. 2017; 8(60):101165-101174.

PMID: 29254154 PMC: 5731864. DOI: 10.18632/oncotarget.20932.

Modified staging classification for intrahepatic cholangiocarcinoma based on the sixth and seventh editions of the AJCC/UICC TNM staging systems.

Meng Z, Pan W, Hong H, Chen J, Chen Y Medicine (Baltimore). 2017; 96(34):e7891.

PMID: 28834905 PMC: 5572027. DOI: 10.1097/MD.0000000000007891.

Pathology of intrahepatic cholangiocarcinoma.

Vijgen S, Terris B, Rubbia-Brandt L Hepatobiliary Surg Nutr. 2017; 6(1):22-34.

PMID: 28261592 PMC: 5332210. DOI: 10.21037/hbsn.2016.11.04.

References

Yap A, Chen C, Yong C, Kuo F, Wang S, Lin C . Clinicopathological factors impact the survival outcome following the resection of combined hepatocellular carcinoma and cholangiocarcinoma. Surg Oncol. 2012; 22(1):55-60. DOI: 10.1016/j.suronc.2012.09.003. View

Lee D, Do I, Choi K, Sung C, Jang K, Choi D . The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. Mod Pathol. 2011; 25(1):131-9. DOI: 10.1038/modpathol.2011.133. View

Yao X, Wang X, Wang Z, Dai L, Zhang G, Yan Q . Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma. Onco Targets Ther. 2012; 5:255-61. PMC: 3472698. DOI: 10.2147/OTT.S36213. View

Sulpice L, Rayar M, Desille M, Turlin B, Fautrel A, Boucher E . Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma. Hepatology. 2013; 58(6):1992-2000. DOI: 10.1002/hep.26577. View

Okamoto K, Tajima H, Nakanuma S, Sakai S, Makino I, Kinoshita J . Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma. Int J Oncol. 2012; 41(2):573-82. DOI: 10.3892/ijo.2012.1499. View

Dong L, Hou Y, Tan Y, Tang L, Pan Y, Wang M . Prognostic significance of Beclin 1 in intrahepatic cholangiocellular carcinoma. Autophagy. 2011; 7(10):1222-9. DOI: 10.4161/auto.7.10.16610. View

Jiang B, Ge R, Sun L, Zong M, Wei G, Zhang Y . Clinical parameters predicting survival duration after hepatectomy for intrahepatic cholangiocarcinoma. Can J Gastroenterol. 2011; 25(11):603-8. PMC: 3222769. DOI: 10.1155/2011/917097. View

Kang Y, Lee J, Kim S, Han J, Choi B . Intrahepatic mass-forming cholangiocarcinoma: enhancement patterns on gadoxetic acid-enhanced MR images. Radiology. 2012; 264(3):751-60. DOI: 10.1148/radiol.12112308. View

Zhan Q, Shen B, Deng X, Zhu Z, Chen H, Peng C . Clinical and pathological analysis of 27 patients with combined hepatocellular-cholangiocarcinoma in an Asian center. J Hepatobiliary Pancreat Sci. 2011; 19(4):361-9. DOI: 10.1007/s00534-011-0417-2. View

10.

Li M, Dong L, Li S, Tang G, Pan Y, Zhang J . Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection. Cancer Lett. 2013; 337(2):248-53. DOI: 10.1016/j.canlet.2013.05.003. View

11.

Zhou Y, Cao L, Li B, Zhang X, Yin Z . Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma. Hepatobiliary Pancreat Dis Int. 2012; 11(5):532-5. DOI: 10.1016/s1499-3872(12)60219-7. View

12.

Nutthasirikul N, Limpaiboon T, Leelayuwat C, Patrakitkomjorn S, Jearanaikoon P . Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma. Int J Oncol. 2013; 42(4):1181-8. DOI: 10.3892/ijo.2013.1818. View

13.

Yin X, Zheng S, Zhang B, Zhou Y, Chen X, Ren Z . Elevation of serum γ-glutamyltransferase as a predictor of aggressive tumor behaviors and unfavorable prognosis in patients with intrahepatic cholangiocarcinoma: analysis of a large monocenter study. Eur J Gastroenterol Hepatol. 2013; 25(12):1408-14. DOI: 10.1097/MEG.0b013e328364130f. View

14.

Shi R, Yang X, Shen Q, Yang L, Xu Y, Qiu S . High expression of Dickkopf-related protein 1 is related to lymphatic metastasis and indicates poor prognosis in intrahepatic cholangiocarcinoma patients after surgery. Cancer. 2012; 119(5):993-1003. DOI: 10.1002/cncr.27788. View

15.

Liao Q, Li Z, Chen R, Guo N, Zeng B, Cheng D . [Effect of hepatitis C virus core gene transfection on NFAT1 expression in human intrahepatic cholangiocarcinoma cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2012; 32(6):789-93. View

16.

Zheng Y, Nie Y, Taniguchi H . Cellular reprogramming and hepatocellular carcinoma development. World J Gastroenterol. 2014; 19(47):8850-60. PMC: 3870535. DOI: 10.3748/wjg.v19.i47.8850. View

17.

Chen T, Jan Y, Yeh T . K-ras mutation is strongly associated with perineural invasion and represents an independent prognostic factor of intrahepatic cholangiocarcinoma after hepatectomy. Ann Surg Oncol. 2012; 19 Suppl 3:S675-81. DOI: 10.1245/s10434-012-2224-7. View

18.

Komuta M, Spee B, Vander Borght S, De Vos R, Verslype C, Aerts R . Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008; 47(5):1544-56. DOI: 10.1002/hep.22238. View

19.

Igami T, Ebata T, Yokoyama Y, Sugawara G, Takahashi Y, Nagino M . Staging of peripheral-type intrahepatic cholangiocarcinoma: appraisal of the new TNM classification and its modifications. World J Surg. 2011; 35(11):2501-9. DOI: 10.1007/s00268-011-1242-0. View

20.

Kim S, Lee C, Kim B, Kim W, Yeom S, Kim K . Typical and atypical imaging findings of intrahepatic cholangiocarcinoma using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging. J Comput Assist Tomogr. 2012; 36(6):704-9. DOI: 10.1097/RCT.0b013e3182706562. View