Interactions Between Innate and Adaptive Lymphocytes

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2014 Aug 19

PMID 25132095

Citations 103

Authors

Georg Gasteiger

Alexander Y Rudensky

Affiliations

Soon will be listed here.

Abstract

Innate lymphocytes - including natural killer cells and the recently discovered innate lymphoid cells - have crucial roles during infection, tissue injury and inflammation. Innate signals regulate the activation and homeostasis of innate lymphocytes. The contribution of the adaptive immune system to the coordination of innate lymphocyte responses is less well understood. In this Opinion article, we review our current understanding of the interactions between adaptive and innate lymphocytes, and propose a model in which T cells of the adaptive immune system function as antigen-specific sensors for the activation of innate lymphocytes to amplify and instruct local immune responses. We highlight the potential roles of regulatory and helper T cells in these processes, and discuss major questions in the emerging area of crosstalk between adaptive and innate lymphocytes.

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References

Long S, Rieck M, Sanda S, Bollyky J, Samuels P, Goland R . Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes. 2012; 61(9):2340-8. PMC: 3425404. DOI: 10.2337/db12-0049. View

Hepworth M, Monticelli L, Fung T, Ziegler C, Grunberg S, Sinha R . Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013; 498(7452):113-7. PMC: 3699860. DOI: 10.1038/nature12240. View

Gasteiger G, Hemmers S, Firth M, Le Floch A, Huse M, Sun J . IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med. 2013; 210(6):1167-78. PMC: 3674692. DOI: 10.1084/jem.20122462. View

Kirchberger S, Royston D, Boulard O, Thornton E, Franchini F, Szabady R . Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J Exp Med. 2013; 210(5):917-31. PMC: 3646494. DOI: 10.1084/jem.20122308. View

Roediger B, Kyle R, Yip K, Sumaria N, Guy T, Kim B . Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol. 2013; 14(6):564-73. PMC: 4282745. DOI: 10.1038/ni.2584. View

Burzyn D, Kuswanto W, Kolodin D, Shadrach J, Cerletti M, Jang Y . A special population of regulatory T cells potentiates muscle repair. Cell. 2013; 155(6):1282-95. PMC: 3894749. DOI: 10.1016/j.cell.2013.10.054. View

Peng H, Jiang X, Chen Y, Sojka D, Wei H, Gao X . Liver-resident NK cells confer adaptive immunity in skin-contact inflammation. J Clin Invest. 2013; 123(4):1444-56. PMC: 3613925. DOI: 10.1172/JCI66381. View

Dalbeth N, Callan M . A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheum. 2002; 46(7):1763-72. DOI: 10.1002/art.10410. View

Xu W, Di Santo J . Taming the beast within: regulation of innate lymphoid cell homeostasis and function. J Immunol. 2013; 191(9):4489-96. DOI: 10.4049/jimmunol.1301759. View

10.

Klose C, Flach M, Mohle L, Rogell L, Hoyler T, Ebert K . Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 2014; 157(2):340-356. DOI: 10.1016/j.cell.2014.03.030. View

11.

Chang Y, Kim H, Albacker L, Baumgarth N, McKenzie A, Smith D . Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol. 2011; 12(7):631-8. PMC: 3417123. DOI: 10.1038/ni.2045. View

12.

Josefowicz S, Lu L, Rudensky A . Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30:531-64. PMC: 6066374. DOI: 10.1146/annurev.immunol.25.022106.141623. View

13.

Guo L, Junttila I, Paul W . Cytokine-induced cytokine production by conventional and innate lymphoid cells. Trends Immunol. 2012; 33(12):598-606. PMC: 4799496. DOI: 10.1016/j.it.2012.07.006. View

14.

Huster K, Stemberger C, Gasteiger G, Kastenmuller W, Drexler I, Busch D . Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function. J Immunol. 2009; 183(11):6898-902. DOI: 10.4049/jimmunol.0902454. View

15.

Waggoner S, Cornberg M, Selin L, Welsh R . Natural killer cells act as rheostats modulating antiviral T cells. Nature. 2011; 481(7381):394-8. PMC: 3539796. DOI: 10.1038/nature10624. View

16.

Neill D, Wong S, Bellosi A, Flynn R, Daly M, Langford T . Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010; 464(7293):1367-70. PMC: 2862165. DOI: 10.1038/nature08900. View

17.

Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L . Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008; 180(7):4679-86. DOI: 10.4049/jimmunol.180.7.4679. View

18.

Scharton T, Scott P . Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med. 1993; 178(2):567-77. PMC: 2191131. DOI: 10.1084/jem.178.2.567. View

19.

Ghiringhelli F, Menard C, Terme M, Flament C, Taieb J, Chaput N . CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med. 2005; 202(8):1075-85. PMC: 2213209. DOI: 10.1084/jem.20051511. View

20.

Constantinides M, McDonald B, Verhoef P, Bendelac A . A committed precursor to innate lymphoid cells. Nature. 2014; 508(7496):397-401. PMC: 4003507. DOI: 10.1038/nature13047. View