Maternal Periconceptional Alcohol Consumption and Congenital Limb Deficiencies

Overview

Journal Birth Defects Res A Clin Mol Teratol

Publisher Wiley

Date 2014 Aug 19

PMID 25132072

Citations 6

Authors

Kristin M Caspers Conway

Paul A Romitti

Lewis Holmes

Richard S Olney

Sandra D Richardson

Affiliations

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Abstract

Background: Women of childbearing age report high rates of alcohol consumption, which may result in alcohol exposure during early pregnancy. Epidemiological research on congenital limb deficiencies (LDs) and periconceptional exposure to alcohol is inconclusive.

Methods: Data from the National Birth Defects Prevention Study (NBDPS) were examined for associations between LDs and patterns of maternal periconceptional (1 month before conception through the first trimester) alcohol consumption among LD case (n = 906) and unaffected control (n = 8352) pregnancies with expected delivery dates from 10/1997 through 12/2007. Adjusted odds ratios (aORs) and 95% confidence intervals were estimated from unconditional logistic regression analysis for all LDs combined, specific LD subtypes (preaxial/terminal transverse), and LD anatomic groups (upper/lower limbs); interactions with folic acid (FA) supplementation were tested.

Results: When compared with nondrinkers, inverse associations were found between all LDs combined, preaxial, and upper LDs and any reported periconceptional alcohol consumption (aORs ranged from 0.56-0.83), drinking without binging (aORs: 0.53-0.75), and binge drinking (≥4 drinks/occasion) (aORs: 0.64-0.94); however, none of the binge drinking aORs were statistically significant. Stratification by alcohol type showed inverse associations between all LDs combined, preaxial, transverse, and upper and lower LDs for drinking without binging of wine only (aORs: 0.39-0.67) and between all LDs combined and upper LDs for drinking without binging of combinations of alcohol (aORs: 0.63-0.87). FA did not modify observed associations.

Conclusion: Maternal periconceptional alcohol consumption did not emerge as a teratogen for selected LDs in the NBDPS. Future studies should evaluate additional rare LDs among more highly exposed populations.

Citing Articles

How Risky Are Risk Factors? An Analysis of Prenatal Risk Factors in Patients Participating in the Congenital Upper Limb Differences Registry.

Schaeffer T, Canizares M, Wall L, Bohn D, Steinman S, Samora J J Hand Surg Glob Online. 2022; 4(3):147-152.

PMID: 35601517 PMC: 9120783. DOI: 10.1016/j.jhsg.2022.03.001.

Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997-2011.

Fisher S, Howley M, Romitti P, Desrosiers T, Jabs E, Browne M Paediatr Perinat Epidemiol. 2022; 36(6):782-791.

PMID: 35437856 PMC: 9990374. DOI: 10.1111/ppe.12882.

A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.

Cerritelli F, Frasch M, Antonelli M, Viglione C, Vecchi S, Chiera M Front Neurosci. 2021; 15:721605.

PMID: 34616274 PMC: 8488382. DOI: 10.3389/fnins.2021.721605.

Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children's Study.

Kurita H, Motoki N, Inaba Y, Misawa Y, Ohira S, Kanai M Pediatr Res. 2020; 90(2):479-486.

PMID: 33230193 PMC: 8460444. DOI: 10.1038/s41390-020-01274-9.

Vasoactive exposures and risk of amniotic band syndrome and terminal transverse limb deficiencies.

Adrien N, Petersen J, Parker S, Werler M Birth Defects Res. 2020; 112(14):1074-1084.

PMID: 32573119 PMC: 9753286. DOI: 10.1002/bdr2.1740.

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