Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2014 Aug 16

PMID 25126099

Citations 6

Authors

Aline Cavalcanti de Queiroz

Thays de Lima Matos Freire Dias

Carolina Barbosa Brito da Matta

Luiz Henrique Agra Cavalcante Silva

Joao Xavier de Araujo-Junior

Givanildo Bernardino de Araujo

Flavia de Barros Prado Moura

Magna Suzana Alexandre-Moreira

Affiliations

Soon will be listed here.

Abstract

This study investigates the leishmanicidal activity of five species of plants used in folk medicine in endemic areas of the state of Alagoas, Brazil. Data were collected in the cities of Colonia Leopoldina, Novo Lino, and União dos Palmares, Alagoas state, from patients with cutaneous leishmaniasis (Leishmania amazonensis) who use medicinal plants to treat this disease. Plants extracts were tested at a concentration of 1-100 μg/mL in all experiments, except in an assay to evaluate activity against amastigotes, when 10 μg/mL was used. All plants extracts did not show deleterious activity to the host cell evidenced by LDH assay at 100, 10, and 1 μg/mL after 48 h of incubation. The plants extracts Hyptis pectinata (L.) Poit, Aloe vera L., Ruta graveolens L., Pfaffia glomerata (Spreng.) Pedersen, and Chenopodium ambrosioides L. exhibited direct activity against extracellular forms at 100 μg/mL; these extracts inhibited growth by 81.9%, 82.9%, 74.4%, 88.7%, and 87.4%, respectively, when compared with promastigotes. The plants extracts H. pectinata, A. vera, and R. graveolens also significantly diminished the number of amastigotes at 10 μg/mL, inhibiting growth by 85.0%, 40.4%, 94.2%, and 97.4%, respectively, when compared with control. Based on these data, we conclude that the five plants exhibited considerable leishmanicidal activity.

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