Age-related Differences in the Activity of Arterial Mineral Deposition and Regional Bone Metabolism: a 18F-sodium Fluoride Positron Emission Tomography Study

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2014 Aug 16

PMID 25124219

Citations 8

Authors

T Derlin

T Janssen

J Salamon

S Veldhoen

J D Busch

G Schon

J Herrmann

F O Henes

P Bannas

G Adam

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Functional (18)F-fluoride PET demonstrated an inverse relationship between the activity of arterial mineral deposition and regional bone metabolism. While bone metabolism decreases with age, the activity of arterial mineral deposition increases.

Introduction: The extent of arterial calcification increases with age, whereas bone mineral density decreases, evidencing a well-known inverse correlation on morphological basis. The aim of this study was to evaluate the functional relationship between the activity of arterial mineral deposition and regional bone metabolism as assessed by (18)F-sodium fluoride (NaF) PET/CT.

Methods: Three hundred four subjects were examined by (18)F-NaF PET/CT. Tracer accumulation in the femoral arteries was analyzed both qualitatively and semiquantitatively by measuring the blood-pool-corrected standardized uptake value (target-to-background ratio). Uptake was compared with cardiovascular risk factors (RFs), calcified plaque burden, and regional bone metabolism as assessed by PET/CT.

Results: The activity of arterial mineral deposition significantly increased with age (p < 0.001), whereas regional bone metabolism significantly decreased (p < 0.001). There was a significant inverse correlation between bone metabolism and arterial mineral deposition (unadjusted, p < 0.001); that association was not significant (p = 0.79) when controlled for age and other RFs. Both high activity of arterial mineral deposition and low bone metabolism were significantly associated with cardiovascular events and other RFs.

Conclusion: (18)F-NaF PET/CT provides a tool to visualize and quantify the activity of arterial mineral deposition and regional bone metabolism. In this study, we observed an inverse correlation between the activity of arterial mineral deposition and regional bone metabolism. While the activity of arterial mineral deposition significantly increases with age, regional bone metabolism decreases.

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References

Blomberg B, Thomassen A, Takx R, Vilstrup M, Hess S, Nielsen A . Delayed sodium 18F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: results from the CAMONA study. J Nucl Cardiol. 2013; 21(2):293-304. DOI: 10.1007/s12350-013-9829-5. View

Bucay N, Sarosi I, Dunstan C, Morony S, Tarpley J, Capparelli C . osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998; 12(9):1260-8. PMC: 316769. DOI: 10.1101/gad.12.9.1260. View

Hofbauer L, Brueck C, Shanahan C, Schoppet M, Dobnig H . Vascular calcification and osteoporosis--from clinical observation towards molecular understanding. Osteoporos Int. 2006; 18(3):251-9. DOI: 10.1007/s00198-006-0282-z. View

Frost M, Fogelman I, Blake G, Marsden P, Cook Jr G . Dissociation between global markers of bone formation and direct measurement of spinal bone formation in osteoporosis. J Bone Miner Res. 2004; 19(11):1797-804. DOI: 10.1359/JBMR.040818. View

Tanko L, Christiansen C, Cox D, Geiger M, McNabb M, Cummings S . Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res. 2005; 20(11):1912-20. DOI: 10.1359/JBMR.050711. View

Janssen T, Bannas P, Herrmann J, Veldhoen S, Busch J, Treszl A . Association of linear ¹⁸F-sodium fluoride accumulation in femoral arteries as a measure of diffuse calcification with cardiovascular risk factors: a PET/CT study. J Nucl Cardiol. 2013; 20(4):569-77. DOI: 10.1007/s12350-013-9680-8. View

Laroche M, Pouilles J, Ribot C, Bendayan P, Bernard J, Boccalon H . Comparison of the bone mineral content of the lower limbs in men with ischaemic atherosclerotic disease. Clin Rheumatol. 1994; 13(4):611-4. DOI: 10.1007/BF02243003. View

Doherty T, Asotra K, Fitzpatrick L, Qiao J, Wilkin D, Detrano R . Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci U S A. 2003; 100(20):11201-6. PMC: 208734. DOI: 10.1073/pnas.1932554100. View

Bagger Y, Tanko L, Alexandersen P, Qin G, Christiansen C . Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med. 2006; 259(6):598-605. DOI: 10.1111/j.1365-2796.2006.01640.x. View

10.

Bural G, Torigian D, Chamroonrat W, Houseni M, Chen W, Basu S . FDG-PET is an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging. 2007; 35(3):562-9. DOI: 10.1007/s00259-007-0528-9. View

11.

Derlin T, Wisotzki C, Richter U, Apostolova I, Bannas P, Weber C . In vivo imaging of mineral deposition in carotid plaque using 18F-sodium fluoride PET/CT: correlation with atherogenic risk factors. J Nucl Med. 2011; 52(3):362-8. DOI: 10.2967/jnumed.110.081208. View

12.

Schwartz A, Sellmeyer D, Strotmeyer E, Tylavsky F, Feingold K, Resnick H . Diabetes and bone loss at the hip in older black and white adults. J Bone Miner Res. 2005; 20(4):596-603. DOI: 10.1359/JBMR.041219. View

13.

Derlin T, Toth Z, Papp L, Wisotzki C, Apostolova I, Habermann C . Correlation of inflammation assessed by 18F-FDG PET, active mineral deposition assessed by 18F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study. J Nucl Med. 2011; 52(7):1020-7. DOI: 10.2967/jnumed.111.087452. View

14.

Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q . Plasma lipids and osteoporosis in postmenopausal women. Endocr J. 2002; 49(2):211-7. DOI: 10.1507/endocrj.49.211. View

15.

Beheshti M, Saboury B, Mehta N, Torigian D, Werner T, Mohler E . Detection and global quantification of cardiovascular molecular calcification by fluoro18-fluoride positron emission tomography/computed tomography--a novel concept. Hell J Nucl Med. 2011; 14(2):114-20. View

16.

Dweck M, Khaw H, Sng G, Luo E, Baird A, Williams M . Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?. Eur Heart J. 2013; 34(21):1567-74. DOI: 10.1093/eurheartj/eht034. View

17.

Kiel D, Kauppila L, Cupples L, Hannan M, ODonnell C, Wilson P . Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int. 2001; 68(5):271-6. DOI: 10.1007/BF02390833. View

18.

Kurata S, Shizukuishi K, Tateishi U, Yoneyama T, Hino A, Ishibashi M . Age-related changes in pre- and postmenopausal women investigated with 18F-fluoride PET--a preliminary study. Skeletal Radiol. 2011; 41(8):947-53. DOI: 10.1007/s00256-011-1318-9. View

19.

Piert M, Zittel T, Becker G, Jahn M, Stahlschmidt A, Maier G . Assessment of porcine bone metabolism by dynamic. J Nucl Med. 2001; 42(7):1091-100. View

20.

Luo G, Ducy P, McKee M, Pinero G, Loyer E, Behringer R . Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997; 386(6620):78-81. DOI: 10.1038/386078a0. View