Estrogens and Stem Cells in Thyroid Cancer

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2014 Aug 15

PMID 25120531

Citations 10

Authors

Mariangela Zane

Veronica Catalano

Emanuela Scavo

Marco Bonanno

Maria Rosa Pelizzo

Matilde Todaro

Giorgio Stassi

Affiliations

Soon will be listed here.

Abstract

Recent discoveries highlight the emerging role of estrogens in the initiation and progression of different malignancies through their interaction with stem cell (SC) compartment. Estrogens play a relevant role especially for those tumors bearing a gender disparity in incidence and aggressiveness, as occurs for most thyroid diseases. Although several experimental lines suggest that estrogens promote thyroid cell proliferation and invasion, their precise contribution in SC compartment still remains unclear. This review underlines the interplay between hormones and thyroid function, which could help to complete the puzzle of gender discrepancy in thyroid malignancies. Defining the association between estrogen receptors' status and signaling pathways by which estrogens exert their effects on thyroid cells is a potential tool that provides important insights in pathogenetic mechanisms of thyroid tumors.

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References

Bellelli R, Castellone M, Garcia-Rostan G, Ugolini C, Nucera C, Sadow P . FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma. Endocr Relat Cancer. 2012; 19(5):695-710. PMC: 3637951. DOI: 10.1530/ERC-12-0031. View

Plateroti M, Kress E, Mori J, Samarut J . Thyroid hormone receptor alpha1 directly controls transcription of the beta-catenin gene in intestinal epithelial cells. Mol Cell Biol. 2006; 26(8):3204-14. PMC: 1446951. DOI: 10.1128/MCB.26.8.3204-3214.2006. View

Acconcia F, Kumar R . Signaling regulation of genomic and nongenomic functions of estrogen receptors. Cancer Lett. 2005; 238(1):1-14. DOI: 10.1016/j.canlet.2005.06.018. View

Cheng S, Leonard J, Davis P . Molecular aspects of thyroid hormone actions. Endocr Rev. 2010; 31(2):139-70. PMC: 2852208. DOI: 10.1210/er.2009-0007. View

Kim W, Lewis C, McCall K, Malgor R, Kohn A, Moon R . Overexpression of Wnt-1 in thyrocytes enhances cellular growth but suppresses transcription of the thyroperoxidase gene via different signaling mechanisms. J Endocrinol. 2007; 193(1):93-106. DOI: 10.1677/JOE-06-0025. View

Lan L, Cui D, Nowka K, Derwahl M . Stem cells derived from goiters in adults form spheres in response to intense growth stimulation and require thyrotropin for differentiation into thyrocytes. J Clin Endocrinol Metab. 2007; 92(9):3681-8. DOI: 10.1210/jc.2007-0281. View

Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G . Mechanisms of estrogen action. Physiol Rev. 2001; 81(4):1535-65. DOI: 10.1152/physrev.2001.81.4.1535. View

Nakada D, Oguro H, Levi B, Ryan N, Kitano A, Saitoh Y . Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature. 2014; 505(7484):555-8. PMC: 4015622. DOI: 10.1038/nature12932. View

Jiang K, Yang Z, Cheng L, Wang S, Ning K, Zhou L . Mediator of ERBB2-driven cell motility (MEMO) promotes extranuclear estrogen receptor signaling involving the growth factor receptors IGF1R and ERBB2. J Biol Chem. 2013; 288(34):24590-9. PMC: 3750157. DOI: 10.1074/jbc.M113.467837. View

10.

Chu R, van Hasselt A, Vlantis A, Ng E, Liu S, Fan M . The cross-talk between estrogen receptor and peroxisome proliferator-activated receptor gamma in thyroid cancer. Cancer. 2013; 120(1):142-53. DOI: 10.1002/cncr.28383. View

11.

Todaro M, Iovino F, Eterno V, Cammareri P, Gambara G, Espina V . Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res. 2010; 70(21):8874-85. DOI: 10.1158/0008-5472.CAN-10-1994. View

12.

Antico-Arciuch V, Dima M, Liao X, Refetoff S, Di Cristofano A . Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females. Oncogene. 2010; 29(42):5678-86. PMC: 2967724. DOI: 10.1038/onc.2010.308. View

13.

Matsuo K, Friedman E, Gejman P, Fagin J . The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms. J Clin Endocrinol Metab. 1993; 76(6):1446-51. DOI: 10.1210/jcem.76.6.8501149. View

14.

Zheng X, Cui D, Xu S, Brabant G, Derwahl M . Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: characterization of resistant cells. Int J Oncol. 2010; 37(2):307-15. DOI: 10.3892/ijo_00000679. View

15.

Fagman H, Nilsson M . Morphogenetics of early thyroid development. J Mol Endocrinol. 2011; 46(1):R33-42. DOI: 10.1677/jme-10-0084. View

16.

Hoffmann S, Glaser S, Wunderlich A, Lingelbach S, Dietrich C, Burchert A . Targeting the EGF/VEGF-R system by tyrosine-kinase inhibitors--a novel antiproliferative/antiangiogenic strategy in thyroid cancer. Langenbecks Arch Surg. 2006; 391(6):589-96. DOI: 10.1007/s00423-006-0104-y. View

17.

Kursawe R, Paschke R . Modulation of TSHR signaling by posttranslational modifications. Trends Endocrinol Metab. 2007; 18(5):199-207. DOI: 10.1016/j.tem.2007.05.002. View

18.

Manole D, Schildknecht B, Gosnell B, Adams E, Derwahl M . Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms. J Clin Endocrinol Metab. 2001; 86(3):1072-7. DOI: 10.1210/jcem.86.3.7283. View

19.

Bjornstrom L, Sjoberg M . Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol. 2005; 19(4):833-42. DOI: 10.1210/me.2004-0486. View

20.

Vaiman M, Olevson Y, Sandbank J, Habler L, Zehavi S, Kessler A . Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue?. Eur Arch Otorhinolaryngol. 2010; 267(11):1753-7. DOI: 10.1007/s00405-010-1269-0. View