Comparison of the Long-term Effects on Rabbit Bone Defects Between Tetrabone and β-tricalcium Phosphate Granules Implantation

Overview

Journal J Artif Organs

Specialty Biomedical Engineering

Date 2014 Aug 14

PMID 25116218

Citations 1

Authors

Sungjin Choi

I-Li Liu

Kenichi Yamamoto

Muneki Honnami

Shinsuke Ohba

Ryosuke Echigo

Takamasa Sakai

Kazuyo Igawa

Shigeki Suzuki

Ryouhei Nishimura

Ung-Il Chung

Nobuo Sasaki

Manabu Mochizuki

Affiliations

Soon will be listed here.

Abstract

Tetrabone is a newly developed granular artificial bone. The 1-mm Tetrabone has a four-legged structure. In this study, the long-term effect of implanting Tetrabone or β-TCP granules in rabbit femoral cylindrical defects was evaluated. The rabbits were euthanized at 4, 13, and 26 weeks after implantation. Micro-CT was conducted to evaluate the residual material volume and the non-osseous tissue volume. New bone tissue areas were measured by histological analysis. Micro-CT imaging showed that the residual material volume in the β-TCP group had decreased significantly at 4 weeks after implantation (P < 0.05) and that the β-TCP granules had nearly disappeared at 26 weeks after implantation. In the Tetrabone group, it did not significantly change until 13 weeks after implantation; it then continued to decrease slightly until 26 weeks after implantation. The non-osseous volume increased in the β-TCP group, whereas that of the Tetrabone group decreased (P < 0.05). Histological examination showed that the new bone areas were significantly greater in the Tetrabone group than in the β-TCP group at 13 and 26 weeks. In conclusion, resorption of β-TCP granules occurs before sufficient bone formation, thereby allowing non-osseous tissue invasion. Tetrabone resorption progressed slowly while the new bone tissues were formed, thus allowing better healing. Tetrabone showed better osteoconductivity, whereas the β-TCP granules lost their function over a long duration. These results may be caused by the differences in the absorption rate of the granules, intergranular pore structure, and crystallinity of each granule.

Citing Articles

Journal of Artificial Organs 2014: the year in review.

Sawa Y, Matsuda K, Tatsumi E, Matsumiya G, Abe T, Fukunaga K J Artif Organs. 2015; 18(1):1-7.

PMID: 25701365 DOI: 10.1007/s10047-015-0821-5.

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