Dengue Virus-specific Cross-reactive CD8+ Human Cytotoxic T Lymphocytes

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1989 Dec 1

PMID 2511337

Citations 37

Authors

J F Bukowski

I Kurane

C J Lai

M Bray

B Falgout

F A Ennis

Affiliations

Soon will be listed here.

Abstract

Stimulation with live dengue virus of peripheral blood mononuclear cells from a dengue virus type 4-immune donor generated virus-specific, serotype-cross-reactive, CD8+, class I-restricted cytotoxic T lymphocytes (CTL) capable of lysing dengue virus-infected cells and cells pulsed with dengue virus antigens of all four serotypes. These CTL lysed autologous fibroblasts infected with vaccinia virus-dengue virus recombinant viruses containing the E gene or several nonstructural dengue virus type 4 genes. These results demonstrate that both dengue virus structural and nonstructural proteins are targets for the cytotoxic T-cell-mediated immune response to dengue virus and suggest that serotype-cross-reactive CD8+ CTL may be important mediators of viral clearance and of virus-induced immunopathology during secondary dengue virus infections.

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References

Halstead S, ORourke E . Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med. 1977; 146(1):201-17. PMC: 2180729. DOI: 10.1084/jem.146.1.201. View

Sly W, Sekhon G, Kennett R, Bodmer W, Bodmer J . Permanent lymphoid lines from genetically marked lymphocytes: success with lymphocytes recovered from frozen storage. Tissue Antigens. 1976; 7(3):165-72. DOI: 10.1111/j.1399-0039.1976.tb01047.x. View

Halstead S . The Alexander D. Langmuir Lecture. The pathogenesis of dengue. Molecular epidemiology in infectious disease. Am J Epidemiol. 1981; 114(5):632-48. DOI: 10.1093/oxfordjournals.aje.a113235. View

Kress H, Kreth H . HLA restriction of secondary mumps-specific cytotoxic T lymphocytes. J Immunol. 1982; 129(2):844-9. View

Halstead S, Larsen K, Kliks S, Peiris J, Cardosa J, PORTERFIELD J . Comparison of P388D1 mouse macrophage cell line and human monocytes for assay of dengue-2 infection-enhancing antibodies. Am J Trop Med Hyg. 1983; 32(1):157-63. DOI: 10.4269/ajtmh.1983.32.157. View

Guyre P, Morganelli P, Miller R . Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes. J Clin Invest. 1983; 72(1):393-7. PMC: 1129195. DOI: 10.1172/jci110980. View

Jacobson S, Richert J, Biddison W, Satinsky A, Hartzman R, McFarland H . Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens. J Immunol. 1984; 133(2):754-7. View

Byrne J, Oldstone M . Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J Virol. 1984; 51(3):682-6. PMC: 255828. DOI: 10.1128/JVI.51.3.682-686.1984. View

Trinchieri G, Clark S, Seehra J, London L, Perussia B . Response of resting human peripheral blood natural killer cells to interleukin 2. J Exp Med. 1984; 160(4):1147-69. PMC: 2187474. DOI: 10.1084/jem.160.4.1147. View

10.

Kurane I, Hebblewaite D, BRANDT W, Ennis F . Lysis of dengue virus-infected cells by natural cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity. J Virol. 1984; 52(1):223-30. PMC: 254509. DOI: 10.1128/JVI.52.1.223-230.1984. View

11.

Bukowski J, Welsh R . Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells. J Exp Med. 1985; 161(1):257-62. PMC: 2187545. DOI: 10.1084/jem.161.1.257. View

12.

Beutler B, Milsark I, Cerami A . Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science. 1985; 229(4716):869-71. DOI: 10.1126/science.3895437. View

13.

Degliantoni G, Murphy M, Kobayashi M, Francis M, Perussia B, Trinchieri G . Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J Exp Med. 1985; 162(5):1512-30. PMC: 2187923. DOI: 10.1084/jem.162.5.1512. View

14.

Yamada A, Young J, Ennis F . Influenza virus subtype-specific cytotoxic T lymphocytes lyse target cells coated with a protein produced in E. coli. J Exp Med. 1985; 162(5):1720-5. PMC: 2187928. DOI: 10.1084/jem.162.5.1720. View

15.

Celis E, Miller R, WIKTOR T, Dietzschold B, KOPROWSKI H . Isolation and characterization of human T cell lines and clones reactive to rabies virus: antigen specificity and production of interferon-gamma. J Immunol. 1986; 136(2):692-7. View

16.

Morrison L, Lukacher A, Braciale V, Fan D, Braciale T . Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones. J Exp Med. 1986; 163(4):903-21. PMC: 2188068. DOI: 10.1084/jem.163.4.903. View

17.

Lindsley M, Torpey 3rd D, Rinaldo Jr C . HLA-DR-restricted cytotoxicity of cytomegalovirus-infected monocytes mediated by Leu-3-positive T cells. J Immunol. 1986; 136(8):3045-51. View

18.

Chakrabarti S, Brechling K, Moss B . Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques. Mol Cell Biol. 1985; 5(12):3403-9. PMC: 369169. DOI: 10.1128/mcb.5.12.3403-3409.1985. View

19.

Schlesinger J, Brandriss M, Walsh E . Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1. J Gen Virol. 1987; 68 ( Pt 3):853-7. DOI: 10.1099/0022-1317-68-3-853. View

20.

Maurer D, Hanke J, Mickelson E, Rich R, Pollack M . Differential presentation of HLA-DR, DQ, and DP restriction elements by interferon-gamma-treated dermal fibroblasts. J Immunol. 1987; 139(3):715-23. View