Two Novel Toxin Variants Revealed by Whole-genome Sequencing of 175 Clostridium Botulinum Type E Strains

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2014 Aug 10

PMID 25107978

Citations 13

Authors

K A Weedmark

D L Lambert

P Mabon

K L Hayden

C J Urfano

D Leclair

G Van Domselaar

J W Austin

C R Corbett

Affiliations

Soon will be listed here.

Abstract

We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay.

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