Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2014 Aug 8

PMID 25100062

Citations 217

Authors

Stephan Hardiville

Gerald W Hart

Affiliations

Soon will be listed here.

Abstract

The nutrient sensor, O-linked N-acetylglucosamine (O-GlcNAc), cycles on and off nuclear and cytosolic proteins to regulate many cellular processes, including transcription and signaling. Dysregulated O-GlcNAcylation and its interplay with phosphorylation contribute to the etiology of diabetes, cancer, and neurodegeneration. Herein, we review recent findings about O-GlcNAc's regulation of cell physiology.

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