Galectins in Epithelial Functions

Overview

Journal Tissue Barriers

Specialties Anatomy & Histology
Biology
Physiology

Date 2014 Aug 7

PMID 25097826

Citations 24

Authors

Mireille Viguier

Tamara Advedissian

Delphine Delacour

Francoise Poirier

Frederique Deshayes

Affiliations

Soon will be listed here.

Abstract

Galectins are a family of animal lectins comprising 15 members in vertebrates. These proteins are involved in many biological processes including epithelial homeostasis and tumor progression by displaying intracellular and extracellular activities. Hence Galectins can be found either in the cytoplasm or the nucleus, associated with membranes or in the extracellular matrix. Current studies aim at understanding the roles of Galectins in cell-cell and cell-matrix adhesion, cellular polarity and motility. This review discusses recent progress in defining the specificities and mechanisms of action of Galectins as cell regulators in epithelial cells. Physiological, cellular and molecular aspects of Galectin specificities will be treated successively.

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References

Mishra R, Grzybek M, Niki T, Hirashima M, Simons K . Galectin-9 trafficking regulates apical-basal polarity in Madin-Darby canine kidney epithelial cells. Proc Natl Acad Sci U S A. 2010; 107(41):17633-8. PMC: 2955135. DOI: 10.1073/pnas.1012424107. View

Lepur A, Salomonsson E, Nilsson U, Leffler H . Ligand induced galectin-3 protein self-association. J Biol Chem. 2012; 287(26):21751-6. PMC: 3381137. DOI: 10.1074/jbc.C112.358002. View

Ingrassia L, Camby I, Lefranc F, Mathieu V, Nshimyumukiza P, Darro F . Anti-galectin compounds as potential anti-cancer drugs. Curr Med Chem. 2006; 13(29):3513-27. DOI: 10.2174/092986706779026219. View

Ochieng J, Leite-Browning M, Warfield P . Regulation of cellular adhesion to extracellular matrix proteins by galectin-3. Biochem Biophys Res Commun. 1998; 246(3):788-91. DOI: 10.1006/bbrc.1998.8708. View

Gu M, Wang W, Song W, Cooper D, Kaufman S . Selective modulation of the interaction of alpha 7 beta 1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation. J Cell Sci. 1994; 107 ( Pt 1):175-81. DOI: 10.1242/jcs.107.1.175. View

Liu F, Patterson R, Wang J . Intracellular functions of galectins. Biochim Biophys Acta. 2002; 1572(2-3):263-73. DOI: 10.1016/s0304-4165(02)00313-6. View

Dakeng S, Duangmano S, Jiratchariyakul W, U-Pratya Y, Bogler O, Patmasiriwat P . Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus. J Cell Biochem. 2011; 113(1):49-60. PMC: 3245346. DOI: 10.1002/jcb.23326. View

Stillman B, Hsu D, Pang M, Brewer C, Johnson P, Liu F . Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death. J Immunol. 2006; 176(2):778-89. DOI: 10.4049/jimmunol.176.2.778. View

Rabinovich G, Alonso C, Sotomayor C, Durand S, Bocco J, Riera C . Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2. Cell Death Differ. 2000; 7(8):747-53. DOI: 10.1038/sj.cdd.4400708. View

10.

Shao W, Yeretssian G, Doiron K, Hussain S, Saleh M . The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem. 2007; 282(50):36321-9. DOI: 10.1074/jbc.M708182200. View

11.

Schneider D, Greb C, Koch A, Straube T, Elli A, Delacour D . Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells. Eur J Cell Biol. 2010; 89(11):788-98. DOI: 10.1016/j.ejcb.2010.07.001. View

12.

Lotz M, Andrews Jr C, Korzelius C, Lee E, Steele Jr G, Clarke A . Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc Natl Acad Sci U S A. 1993; 90(8):3466-70. PMC: 46321. DOI: 10.1073/pnas.90.8.3466. View

13.

Nickel W . The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur J Biochem. 2003; 270(10):2109-19. DOI: 10.1046/j.1432-1033.2003.03577.x. View

14.

Yabuta C, Yano F, Fujii A, Shearer T, Azuma M . Galectin-3 enhances epithelial cell adhesion and wound healing in rat cornea. Ophthalmic Res. 2013; 51(2):96-103. DOI: 10.1159/000355846. View

15.

Schafer T, Zentgraf H, Zehe C, Brugger B, Bernhagen J, Nickel W . Unconventional secretion of fibroblast growth factor 2 is mediated by direct translocation across the plasma membrane of mammalian cells. J Biol Chem. 2003; 279(8):6244-51. DOI: 10.1074/jbc.M310500200. View

16.

Stannard K, Collins P, Ito K, Sullivan E, Scott S, Gabutero E . Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett. 2010; 299(2):95-110. DOI: 10.1016/j.canlet.2010.08.005. View

17.

Hsu D, Chernyavsky A, Chen H, Yu L, Grando S, Liu F . Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells. J Invest Dermatol. 2008; 129(3):573-83. PMC: 2645233. DOI: 10.1038/jid.2008.276. View

18.

Delacour D, Cramm-Behrens C, Drobecq H, Le Bivic A, Naim H, Jacob R . Requirement for galectin-3 in apical protein sorting. Curr Biol. 2006; 16(4):408-14. DOI: 10.1016/j.cub.2005.12.046. View

19.

Cooper D, Barondes S . Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism. J Cell Biol. 1990; 110(5):1681-91. PMC: 2200163. DOI: 10.1083/jcb.110.5.1681. View

20.

Levy Y, Hadari Y, Eshhar S, Ronen D, Elhanany E, Geiger B . Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 2001; 276(33):31285-95. DOI: 10.1074/jbc.M100340200. View