The Effect of Tranexamic Acid on Artificial Joint Materials: a Biomechanical Study (the BioTRANX Study)

Overview

Journal J Orthop Traumatol

Specialties Emergency Medicine
Orthopedics

Date 2014 Aug 6

PMID 25091616

Citations 5

Authors

Sattar Alshryda

James M Mason

Praveen Sarda

T Lou

Martin Stanley

Junjie Wu

Anthony Unsworth

Affiliations

Soon will be listed here.

Abstract

Background: Tranexamic acid (TXA) has been successfully used to reduce bleeding in joint replacement. Recently local TXA has been advocated to reduce blood loss in total knee or hip replacement; however, this raised concerns about potential adverse effects of TXA upon the artificial joint replacement.

Materials And Methods: In this biomechanical study we compared the effects of TXA and saline upon the following biomechanical properties of artificial joint materials-(1) tensile properties (ultimate strength, stiffness and Young's modulus), (2) the wear rate using a multi-directional pin-on-plate machine, and (3) the surface topography of pins and plates before and after wear rate testing.

Results: There were no significant differences in tensile strength, wear rates or surface topography of either ultra-high-molecular-weight polyethylene pins or cobalt chromium molybdenum metal plates between specimens soaked in TXA and specimens soaked in saline.

Conclusion: Biomechanical testing shows that there are no biomechanical adverse affects on the properties of common artificial joint materials from using topical TXA.

Level Of Evidence: V.

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