HLA and KIR Genotyping Correlates with Relapse After T-cell-replete Haploidentical Transplantation in Chronic Myeloid Leukaemia Patients

Overview

Journal Br J Cancer

Specialty Oncology

Date 2014 Aug 1

PMID 25077441

Citations 9

Authors

X-Y Zhao

Y-J Chang

L-P Xu

X-H Zhang

K-Y Liu

D Li

X-J Huang

Affiliations

Soon will be listed here.

Abstract

Background: Conflicting results have been reported regarding the predicative roles of alloreactive natural killer (NK) cells on the outcomes of transplantation in leukaemia patients.

Methods: We prospectively analysed the human leukocyte antigen (HLA) typing of donor-recipient pairs and the KIR typing of the donors in 97 CML patients to address the predictive roles of NK cells in relapse undergoing T-cell-replete haploidentical transplantation.

Results: Patients with class I ligands for the donor-inhibitory KIR gene exhibited decreased molecular and haematologic relapse rates (P=0.003 and P=0.015, respectively). There was a significantly reduced risk of molecular and haematologic relapse in patients with HLA-C1C2 or C2C2 who accepted donors with KIR2DS1 or in patients with HLA-Bw4 who accepted donors with KIR3DS1 ('recipient with relevant KIR ligand for donor-activating KIR', n=25), compared with the remaining transplants (n=72, P=0.009 and P=0.009, respectively). In addition, the presence of class I ligand in the recipients of donor-activating KIR contributed to a decreased relapse rate in patients lacking class I ligand in the recipient of donor-inhibitory KIR (P=0.04 and P=0.03, respectively).

Conclusions: This study suggests that the presence of class I ligands for the donor-activating or donor-inhibitory KIR gene in the recipient might confer some protection against leukaemic relapse in T-cell-replete haploidentical transplantation.

Citing Articles

[The impact of donor human leukocyte antigen-Bw4 allele on natural killer cell reconstitution and transplant-related mortality in haploidentical transplantation].

Zhao M, Xu Z, Yu X, Ding Y, Chang Y, Zhang X Zhonghua Xue Ye Xue Za Zhi. 2024; 45(5):453-461.

PMID: 38964919 PMC: 11270487. DOI: 10.3760/cma.j.cn.121090-20240314-00094.

The role and novel use of natural killer cells in graft-versus-leukemia reactions after allogeneic transplantation.

Hadjis A, McCurdy S Front Immunol. 2024; 15:1358668.

PMID: 38817602 PMC: 11137201. DOI: 10.3389/fimmu.2024.1358668.

Leveraging Natural Killer Cell Innate Immunity against Hematologic Malignancies: From Stem Cell Transplant to Adoptive Transfer and Beyond.

Lin C, Horwitz M, Rein L Int J Mol Sci. 2023; 24(1).

PMID: 36613644 PMC: 9820370. DOI: 10.3390/ijms24010204.

DR2S: an integrated algorithm providing reference-grade haplotype sequences from heterozygous samples.

Klasberg S, Schmidt A, Lange V, Schofl G BMC Bioinformatics. 2021; 22(1):236.

PMID: 33971817 PMC: 8111713. DOI: 10.1186/s12859-021-04153-0.

Influence of KIR and NK Cell Reconstitution in the Outcomes of Hematopoietic Stem Cell Transplantation.

Gao F, Ye Y, Gao Y, Huang H, Zhao Y Front Immunol. 2020; 11:2022.

PMID: 32983145 PMC: 7493622. DOI: 10.3389/fimmu.2020.02022.

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