Renal Subanalysis of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF): the End of Nesiritide As a Cardiorenal Therapeutic?

Overview

Journal Circulation

Specialty Cardiology & Vascular Diseases

Date 2014 Jul 31

PMID 25074508

Citations 1

Authors

Jeffrey M Testani

Affiliations

Soon will be listed here.

Citing Articles

Cyclic nucleotide signalling in kidney fibrosis.

Schinner E, Wetzl V, Schlossmann J Int J Mol Sci. 2015; 16(2):2320-51.

PMID: 25622251 PMC: 4346839. DOI: 10.3390/ijms16022320.

References

Wang D, Dowling T, Meadows D, Ayala T, Marshall J, Minshall S . Nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine. Circulation. 2004; 110(12):1620-5. DOI: 10.1161/01.CIR.0000141829.04031.25. View

Massie B, OConnor C, Metra M, Ponikowski P, Teerlink J, Cotter G . Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. N Engl J Med. 2010; 363(15):1419-28. DOI: 10.1056/NEJMoa0912613. View

Cataliotti A, Burnett Jr J . Natriuretic peptides: novel therapeutic targets in heart failure. J Investig Med. 2005; 53(7):378-84. DOI: 10.2310/6650.2005.53711. View

. Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA. 2002; 287(12):1531-40. DOI: 10.1001/jama.287.12.1531. View

Chen H, Anstrom K, Givertz M, Stevenson L, Semigran M, Goldsmith S . Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA. 2013; 310(23):2533-43. PMC: 3934929. DOI: 10.1001/jama.2013.282190. View

Bart B, Goldsmith S, Lee K, Givertz M, OConnor C, Bull D . Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med. 2012; 367(24):2296-304. PMC: 3690472. DOI: 10.1056/NEJMoa1210357. View

Konstam M, Gheorghiade M, Burnett Jr J, Grinfeld L, Maggioni A, Swedberg K . Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA. 2007; 297(12):1319-31. DOI: 10.1001/jama.297.12.1319. View

OConnor C, Starling R, Hernandez A, Armstrong P, Dickstein K, Hasselblad V . Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011; 365(1):32-43. DOI: 10.1056/NEJMoa1100171. View

Felker G, Lee K, Bull D, Redfield M, Stevenson L, Goldsmith S . Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med. 2011; 364(9):797-805. PMC: 3412356. DOI: 10.1056/NEJMoa1005419. View

10.

Hernandez A, OConnor C, Starling R, Reist C, Armstrong P, Dickstein K . Rationale and design of the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial (ASCEND-HF). Am Heart J. 2009; 157(2):271-7. DOI: 10.1016/j.ahj.2008.07.031. View

11.

Sackner-Bernstein J, Kowalski M, Fox M, Aaronson K . Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials. JAMA. 2005; 293(15):1900-5. DOI: 10.1001/jama.293.15.1900. View

12.

Testani J, McCauley B, Chen J, Shumski M, Shannon R . Worsening renal function defined as an absolute increase in serum creatinine is a biased metric for the study of cardio-renal interactions. Cardiology. 2010; 116(3):206-12. PMC: 2992648. DOI: 10.1159/000316038. View

13.

Sackner-Bernstein J, Skopicki H, Aaronson K . Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure. Circulation. 2005; 111(12):1487-91. DOI: 10.1161/01.CIR.0000159340.93220.E4. View

14.

Gerhard T, Zineh I, Winterstein A, Hartzema A . Pharmacoeconomic modeling of nesiritide versus dobutamine for decompensated heart failure. Pharmacotherapy. 2006; 26(1):34-43. DOI: 10.1592/phco.2006.26.1.34. View

15.

Gottlieb S, Stebbins A, Voors A, Hasselblad V, Ezekowitz J, Califf R . Effects of nesiritide and predictors of urine output in acute decompensated heart failure: results from ASCEND-HF (acute study of clinical effectiveness of nesiritide and decompensated heart failure). J Am Coll Cardiol. 2013; 62(13):1177-83. DOI: 10.1016/j.jacc.2013.04.073. View

16.

van Deursen V, Hernandez A, Stebbins A, Hasselblad V, Ezekowitz J, Califf R . Nesiritide, renal function, and associated outcomes during hospitalization for acute decompensated heart failure: results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF). Circulation. 2014; 130(12):958-65. DOI: 10.1161/CIRCULATIONAHA.113.003046. View