MiR-24 Promotes the Proliferation and Invasion of HCC Cells by Targeting SOX7

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2014 Jul 31

PMID 25073511

Citations 27

Authors

Ying Ma

Xing-Guo She

Ying-Zi Ming

Qi-Quan Wan

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.

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