Inherent Insulin Sensitivity is a Major Determinant of Multimeric Adiponectin Responsiveness to Short-term Weight Loss in Extreme Obesity

Overview

Journal Sci Rep

Specialty Science

Date 2014 Jul 25

PMID 25056918

Citations 4

Authors

Stefania Mai

Gillian E Walker

Amelia Brunani

Gabriele Guzzaloni

Glenda Grossi

Alberto Oldani

Gianluca Aimaretti

Massimo Scacchi

Paolo Marzullo

Affiliations

Soon will be listed here.

Abstract

High molecular weight (HMW-A) adiponectin levels mirror alterations in glucose homeostasis better than medium (MMW-A) and low molecular weight (LMW-A) components. In 25 patients with wide-range extreme obesity (BMI 40-77 kg/m(2)), we aimed to explore if improvements of multimeric adiponectin following 4-wk weight loss reflect baseline OGTT-derived insulin sensitivity (ISIOGTT) and disposition index (DIOGTT). Compared to 40 lean controls, adiponectin oligomers were lower in extreme obesity (p < 0.001) and, within this group, HMW-A levels were higher in insulin-sensitive (p < 0.05) than -resistant patients. In obese patients, short-term weight loss did not change total adiponectin levels and insulin resistance, while the distribution pattern of adiponectin oligomers changed due to significant increment of HMW-A (p < 0.01) and reduction of MMW-A (p < 0.05). By multivariate analysis, final HMW-A levels were significantly related to baseline ISIOGTT and final body weight (adjusted R(2) = 0.41). Our data suggest that HMW adiponectin may reflect baseline insulin sensitivity appropriately in the context of extreme obesity. Especially, we documented that HMW-A is promptly responsive to short-term weight loss prior to changes in insulin resistance, by a magnitude that is proportioned to whole body insulin sensitivity. This may suggest an insulin sensitivity-dependent control operated by HMW-A on metabolic dynamics of patients with extreme obesity.

Citing Articles

Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction.

Engin A Adv Exp Med Biol. 2024; 1460:431-462.

PMID: 39287861 DOI: 10.1007/978-3-031-63657-8_15.

Effect of a weight loss program on serum adiponectin and insulin resistance among overweight and obese premenopausal females.

Foula W, Emara R, ElDeeb M, Mokhtar S, El-Sahn F J Egypt Public Health Assoc. 2020; 95(1):32.

PMID: 33259020 PMC: 7708549. DOI: 10.1186/s42506-020-00060-z.

Acute Vitamin D₃ Supplementation in Severe Obesity: Evaluation of Multimeric Adiponectin.

Mai S, Walker G, Vietti R, Cattaldo S, Mele C, Priano L Nutrients. 2017; 9(5).

PMID: 28475159 PMC: 5452189. DOI: 10.3390/nu9050459.

Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity.

Weiss E, Reeds D, Ezekiel U, Albert S, Villareal D Endocrine. 2016; 55(1):153-164.

PMID: 27605038 PMC: 5226911. DOI: 10.1007/s12020-016-1093-4.

References

Bastard J, Maachi M, Lagathu C, Kim M, Caron M, Vidal H . Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006; 17(1):4-12. View

Wang Y, Lam K, Yau M, Xu A . Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J. 2008; 409(3):623-33. DOI: 10.1042/BJ20071492. View

Nishida M, Funahashi T, Shimomura I . Pathophysiological significance of adiponectin. Med Mol Morphol. 2007; 40(2):55-67. DOI: 10.1007/s00795-007-0366-7. View

Bobbert T, Rochlitz H, Wegewitz U, Akpulat S, Mai K, Weickert M . Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes. 2005; 54(9):2712-9. DOI: 10.2337/diabetes.54.9.2712. View

Marzullo P, Verti B, Savia G, Walker G, Guzzaloni G, Tagliaferri M . The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure. J Clin Endocrinol Metab. 2004; 89(2):936-9. DOI: 10.1210/jc.2003-031328. View

Serra A, Granada M, Romero R, Bayes B, Canton A, Bonet J . The effect of bariatric surgery on adipocytokines, renal parameters and other cardiovascular risk factors in severe and very severe obesity: 1-year follow-up. Clin Nutr. 2006; 25(3):400-8. DOI: 10.1016/j.clnu.2005.11.014. View

Lin H, Li Z . Adiponectin self-regulates its expression and multimerization in adipose tissue: an autocrine/paracrine mechanism?. Med Hypotheses. 2011; 78(1):75-8. DOI: 10.1016/j.mehy.2011.07.063. View

Abbasi F, Chu J, Lamendola C, McLaughlin T, Hayden J, Reaven G . Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes. 2004; 53(3):585-90. DOI: 10.2337/diabetes.53.3.585. View

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J . Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999; 257(1):79-83. DOI: 10.1006/bbrc.1999.0255. View

10.

Anderwald C, Anderwald-Stadler M, Promintzer M, Prager G, Mandl M, Nowotny P . The Clamp-Like Index: a novel and highly sensitive insulin sensitivity index to calculate hyperinsulinemic clamp glucose infusion rates from oral glucose tolerance tests in nondiabetic subjects. Diabetes Care. 2007; 30(9):2374-80. DOI: 10.2337/dc07-0422. View

11.

Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, van Haeften T . Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000; 23(3):295-301. DOI: 10.2337/diacare.23.3.295. View

12.

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K . Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006; 116(7):1784-92. PMC: 1483172. DOI: 10.1172/JCI29126. View

13.

Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S . Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem. 2004; 279(29):30817-22. DOI: 10.1074/jbc.M402367200. View

14.

Matsuda M, DeFronzo R . Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999; 22(9):1462-70. DOI: 10.2337/diacare.22.9.1462. View

15.

Polak J, Kovacova Z, Jacek M, Klimcakova E, Kovacikova M, Vitkova M . An increase in plasma adiponectin multimeric complexes follows hypocaloric diet-induced weight loss in obese and overweight pre-menopausal women. Clin Sci (Lond). 2007; 112(11):557-65. DOI: 10.1042/CS20060296. View

16.

Kaser S, Tatarczyk T, Stadlmayr A, Ciardi C, Ress C, Tschoner A . Effect of obesity and insulin sensitivity on adiponectin isoform distribution. Eur J Clin Invest. 2008; 38(11):827-34. DOI: 10.1111/j.1365-2362.2008.02028.x. View

17.

Pajvani U, Hawkins M, Combs T, Rajala M, Doebber T, Berger J . Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2003; 279(13):12152-62. DOI: 10.1074/jbc.M311113200. View

18.

Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi M, Commerford P . Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet. 2005; 366(9497):1640-9. DOI: 10.1016/S0140-6736(05)67663-5. View

19.

Abbasi F, Chang S, Chu J, Ciaraldi T, Lamendola C, McLaughlin T . Improvements in insulin resistance with weight loss, in contrast to rosiglitazone, are not associated with changes in plasma adiponectin or adiponectin multimeric complexes. Am J Physiol Regul Integr Comp Physiol. 2005; 290(1):R139-44. DOI: 10.1152/ajpregu.00287.2005. View

20.

Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y . Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000; 20(6):1595-9. DOI: 10.1161/01.atv.20.6.1595. View