The Role of Colonoscopic Screening in Acromegaly Revisited: Review of Current Literature and Practice Guidelines

Overview

Journal Pituitary

Specialty Endocrinology

Date 2014 Jul 24

PMID 25052731

Citations 17

Authors

K Lois

J Bukowczan

P Perros

S Jones

M Gunn

R A James

Affiliations

Soon will be listed here.

Abstract

Introduction: Acromegaly is a chronic, debilitating and disfiguring condition with a significantly increased morbidity and mortality due to cardiovascular, as well as respiratory complications. Patients with acromegaly are usually diagnosed at the age of 40, however, the duration of symptoms can vary from 5 to 10 years before the formal diagnosis is confirmed. Recent advances in the field of acromegaly have improved survival significantly. A strong association between acromegaly and premalignant colonic lesions and colon cancer has been highlighted. Furthermore, patients with acromegaly have a greater lifetime risk of malignant transformation and a far worse overall prognosis from colorectal cancer, which is now considered a major disease related complication.

Materials And Methods: A comprehensive search strategy was applied for the Medline/PubMed electronic database from its inception until April 2014. We considered all human research articles published in English, not classified as case report, editorial, comment, letter, or news.

Conclusion: Specific recommendations for large bowel endoscopic screening in patients with acromegaly have been proposed. In this comprehensive review we discuss the current state of knowledge and evidence on colonoscopic screening in patients with acromegaly illustrated by a case of aggressive colorectal cancer presenting late in a young woman with difficult to control acromegaly.

Citing Articles

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Practical therapeutic approach in the management of diabetes mellitus secondary to Cushing's syndrome, acromegaly and neuroendocrine tumours.

Guarnotta V, Emanuele F, Salzillo R, Bonsangue M, Amato C, Mineo M Front Endocrinol (Lausanne). 2023; 14:1248985.

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Follow, consider, and catch: second primary tumors in acromegaly patients.

Oguz S, Firlatan B, Sendur S, Dagdelen S, Erbas T Endocrine. 2022; 80(1):160-173.

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Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly.

Peng G, Li X, Zhou Y, Bai J, Hong P, Li W Exp Clin Endocrinol Diabetes. 2022; 130(11):714-722.

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