Resting Energy Expenditure is Not Associated with Disease Activity in Women with Rheumatoid Arthritis: Cross-sectional Study

Overview

Journal Korean J Intern Med

Specialty General Medicine

Date 2014 Jul 22

PMID 25045300

Citations 3

Authors

Jung-Yoon Choe

Sung-Hoon Park

Hwajeong Lee

Hyun Hee Kwon

Seong-Kyu Kim

Affiliations

Soon will be listed here.

Abstract

Background/aims: Increased resting energy expenditure (REE) in rheumatoid arthritis (RA) patients is thought to be caused by hypermetabolism associated with production of proinflammatory cytokines. Our aim in the present study was to explore the possible association between REE and disease activity in females with RA.

Methods: A total of 499 female RA patients were recruited to this cross-sectional study assessing REE scores on disease activity indices (the routine assessment of patient index data 3 [RAPID3], the disease activity score 28, and the clinical/simplified disease activity index [CDAI/SDAI]) and the levels of RA-associated autoantibodies (rheumatoid factor and anticyclic citrullinated peptide [anti-CCP] antibodies). Age-matched healthy female controls (n = 131) were also enrolled.

Results: REE did not differ between RA patients (all patients, and those in remission or not) and controls, or between RA patients in remission or not (p > 0.05 for all comparisons). Increased REE in total RA patients was associated with younger age and a higher body mass index (BMI) (p < 0.001 and p < 0.001, respectively), but not with disease activity index scores on any of RAPID3, CDAI, or SDAI. BMI was the only clinical parameter exhibiting a significant relationship with REE quartiles (Q1 to Q4; p < 0.001); none of disease duration, functional status, or anti-CCP antibody titer in RA patients was significantly related to REE, based on analysis of covariance.

Conclusions: We found no association between REE and disease activity in RA patients, implying that energy metabolism in RA patients might be independent of RA-associated systemic inflammation.

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References

Collins L, Walker J, Stamford B . Smoking multiple high- versus low-nicotine cigarettes: impact on resting energy expenditure. Metabolism. 1996; 45(8):923-6. DOI: 10.1016/s0026-0495(96)90256-5. View

Smolen J, Breedveld F, Schiff M, Kalden J, Emery P, Eberl G . A simplified disease activity index for rheumatoid arthritis for use in clinical practice. Rheumatology (Oxford). 2003; 42(2):244-57. DOI: 10.1093/rheumatology/keg072. View

Muller-Ladner U, Pap T, Gay R, Neidhart M, Gay S . Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol. 2006; 1(2):102-10. DOI: 10.1038/ncprheum0047. View

Lee S, Park M, Yoon H, Park Y, Park I, Park K . Evaluating the Korean version of the Multidimensional Health Assessment Questionnaire in patients with rheumatoid arthritis. Clin Rheumatol. 2005; 25(3):353-7. DOI: 10.1007/s10067-005-0049-5. View

Metsios G, Stavropoulos-Kalinoglou A, Douglas K, Koutedakis Y, Nevill A, Panoulas V . Blockade of tumour necrosis factor-alpha in rheumatoid arthritis: effects on components of rheumatoid cachexia. Rheumatology (Oxford). 2007; 46(12):1824-7. DOI: 10.1093/rheumatology/kem291. View

Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31(3):315-24. DOI: 10.1002/art.1780310302. View

Metsios G, Stavropoulos-Kalinoglou A, Nevill A, Douglas K, Koutedakis Y, Kitas G . Cigarette smoking significantly increases basal metabolic rate in patients with rheumatoid arthritis. Ann Rheum Dis. 2007; 67(1):70-3. DOI: 10.1136/ard.2006.068403. View

Metsios G, Flouris A, Jamurtas A, Carrillo A, Kouretas D, Germenis A . A brief exposure to moderate passive smoke increases metabolism and thyroid hormone secretion. J Clin Endocrinol Metab. 2006; 92(1):208-11. DOI: 10.1210/jc.2006-0762. View

Roubenoff R, Walsmith J, Lundgren N, Snydman L, Dolnikowski G, Roberts S . Low physical activity reduces total energy expenditure in women with rheumatoid arthritis: implications for dietary intake recommendations. Am J Clin Nutr. 2002; 76(4):774-9. DOI: 10.1093/ajcn/76.4.774. View

10.

Marcora S, Chester K, Mittal G, Lemmey A, Maddison P . Randomized phase 2 trial of anti-tumor necrosis factor therapy for cachexia in patients with early rheumatoid arthritis. Am J Clin Nutr. 2006; 84(6):1463-72. DOI: 10.1093/ajcn/84.6.1463. View

11.

Metsios G, Stavropoulos-Kalinoglou A, Panoulas V, Koutedakis Y, Nevill A, Douglas K . New resting energy expenditure prediction equations for patients with rheumatoid arthritis. Rheumatology (Oxford). 2008; 47(4):500-6. DOI: 10.1093/rheumatology/ken022. View

12.

Firestein G . Evolving concepts of rheumatoid arthritis. Nature. 2003; 423(6937):356-61. DOI: 10.1038/nature01661. View

13.

Mifflin M, St Jeor S, Hill L, Scott B, Daugherty S, Koh Y . A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr. 1990; 51(2):241-7. DOI: 10.1093/ajcn/51.2.241. View

14.

Rall L, Rosen C, Dolnikowski G, HARTMAN W, LUNDGREN N, Abad L . Protein metabolism in rheumatoid arthritis and aging. Effects of muscle strength training and tumor necrosis factor alpha. Arthritis Rheum. 1996; 39(7):1115-24. DOI: 10.1002/art.1780390707. View

15.

Aletaha D, Nell V, Stamm T, Uffmann M, Pflugbeil S, Machold K . Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res Ther. 2005; 7(4):R796-806. PMC: 1175030. DOI: 10.1186/ar1740. View

16.

Roubenoff R, Roubenoff R, Ward L, Holland S, Hellmann D . Rheumatoid cachexia: depletion of lean body mass in rheumatoid arthritis. Possible association with tumor necrosis factor. J Rheumatol. 1992; 19(10):1505-10. View

17.

Harris J, Benedict F . A Biometric Study of Human Basal Metabolism. Proc Natl Acad Sci U S A. 1918; 4(12):370-3. PMC: 1091498. DOI: 10.1073/pnas.4.12.370. View

18.

Rall L, Roubenoff R . Rheumatoid cachexia: metabolic abnormalities, mechanisms and interventions. Rheumatology (Oxford). 2004; 43(10):1219-23. DOI: 10.1093/rheumatology/keh321. View

19.

Arshad A, Rashid R, Benjamin K . The effect of disease activity on fat-free mass and resting energy expenditure in patients with rheumatoid arthritis versus noninflammatory arthropathies/soft tissue rheumatism. Mod Rheumatol. 2007; 17(6):470-5. DOI: 10.1007/s10165-007-0628-1. View

20.

Prevoo M, van t Hof M, Kuper H, van Leeuwen M, van de Putte L, van Riel P . Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995; 38(1):44-8. DOI: 10.1002/art.1780380107. View