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A Case of Chronic Myeloid Leukemia with Features of Essential Thrombocythemia in Peripheral Blood and Bone Marrow

Overview
Journal Blood Res
Publisher Springer Nature
Specialty Hematology
Date 2014 Jul 16
PMID 25025015
Citations 5
Authors
Young Jae Byun
Byeong-Bae Park
Eun Sung Lee
Kyung Soo Choi
Dae Sung Lee
Affiliations
Soon will be listed here.
Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by overproduction of myeloid white blood cells. Philadelphia chromosome is an essential finding for CML diagnosis. Generally, a clinical diagnosis of essential thrombocythemia (ET) can be established from isolated marked thrombocytosis in peripheral blood. However, Philadelphia chromosome-positivity or bcr/abl rearrangement with isolated thrombocytosis should be diagnosed as CML, not ET, according to World Health Organization diagnostic criteria. Therefore, CML should not be excluded before confirming the presence of the Philadelphia chromosome or bcr/abl rearrangement in cases of isolated thrombocytosis in peripheral blood. We report a case of CML with clinical features of ET in a patient successfully treated with imatinib.

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References
1.
Stoll D, Peterson P, Exten R, Laszlo J, PISCIOTTA A, Ellis J . Clinical presentation and natural history of patients with essential thrombocythemia and the Philadelphia chromosome. Am J Hematol. 1988; 27(2):77-83. DOI: 10.1002/ajh.2830270202. View
2.
Michiels J, Berneman Z, Schroyens W, Kutti J, Swolin B, Ridell B . Philadelphia (Ph) chromosome-positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood: natural history and diagnostic differentiation from Ph-negative essential thrombocythemia. Ann Hematol. 2004; 83(8):504-12. DOI: 10.1007/s00277-004-0877-4. View
3.
Kwong Y, Chiu E, Liang R, Chan V, Chan T . Essential thrombocythemia with BCR/ABL rearrangement. Cancer Genet Cytogenet. 1996; 89(1):74-6. DOI: 10.1016/0165-4608(94)00108-1. View
4.
OBrien S, Guilhot F, Larson R, Gathmann I, Baccarani M, Cervantes F . Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003; 348(11):994-1004. DOI: 10.1056/NEJMoa022457. View
5.
Savage D, Antman K . Imatinib mesylate--a new oral targeted therapy. N Engl J Med. 2002; 346(9):683-93. DOI: 10.1056/NEJMra013339. View