The Dysexecutive Syndrome of Alzheimer's Disease: the GREFEX Study

Overview

Journal J Alzheimers Dis

Publisher Sage Publications

Specialties Geriatrics
Neurology

Date 2014 Jul 16

PMID 25024318

Citations 14

Authors

Olivier Godefroy

Olivier Martinaud

Marc Verny

Chrystele Mosca

Hermine Lenoir

Eric Bretault

Martine Roussel

Affiliations

Soon will be listed here.

Abstract

Background: Dysexecutive disorders are common in early-stage Alzheimer's disease (AD) but have yet to be characterized in detail.

Objective: The objectives of the present study based on validated diagnostic criteria were to determine the frequency and characterize the profile of behavioral and cognitive dysexecutive disorders in AD.

Methods: 102 patients with AD (mild: n = 92; moderate: n = 10; mean MMSE score: 23.2) were examined with the GREFEX battery. Neuropsychological data were interpreted within a validated framework based on the performance levels of 780 control participants from the GREFEX study.

Results: Dysexecutive syndrome was observed in 87.5% (95%CI: 79-96) of the AD patients (p = 0.0001). The dysexecutive disorder profile was characterized by prominent impairments of planning, inhibition flexibility and generation in the cognitive domain (p = 0.0001 as compared to controls for all) and global hypoactivity in the behavioral domain (p = 0.0001 as compared to controls).

Conclusions: Dysexecutive syndrome is observed in over 80% of AD patients and has a distinct profile.

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