The Multifaceted Nature of Retinoid Transport and Metabolism

Overview

Journal Hepatobiliary Surg Nutr

Publisher AME Publishing Company

Date 2014 Jul 15

PMID 25019074

Citations 70

Authors

Yang Li

Nuttaporn Wongsiriroj

William S Blaner

Affiliations

Soon will be listed here.

Abstract

Since their discovery over a century ago, retinoids have been the most studied of the fat-soluble vitamins. Unlike most vitamins, retinoids are stored at relatively high concentrations in the body to buffer against nutritional insufficiency. Until recently, it was thought that the sole important retinoid delivery pathway to tissues involved retinol bound to retinol-binding protein (RBP4). More recent findings, however, indicate that retinoids can be delivered to tissues through multiple overlapping delivery pathways, involving chylomicrons, very low density lipoprotein (VLDL) and low density lipoprotein (LDL), retinoic acid bound to albumin, water soluble β-glucuronides of retinol and retinoic acid, and provitamin A carotenoids. This review will focus on explaining this evolving understanding of retinoid metabolism and transport within the body.

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References

GOTTESMAN M, Quadro L, Blaner W . Studies of vitamin A metabolism in mouse model systems. Bioessays. 2001; 23(5):409-19. DOI: 10.1002/bies.1059. View

Moriwaki H, Blaner W, Piantedosi R, Goodman D . Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets. J Lipid Res. 1988; 29(11):1523-34. View

Ballew C, Bowman B, Russell R, Sowell A, Gillespie C . Serum retinyl esters are not associated with biochemical markers of liver dysfunction in adult participants in the third National Health and Nutrition Examination Survey (NHANES III), 1988--1994. Am J Clin Nutr. 2001; 73(5):934-40. DOI: 10.1093/ajcn/73.5.934. View

Al Tanoury Z, Piskunov A, Rochette-Egly C . Vitamin A and retinoid signaling: genomic and nongenomic effects. J Lipid Res. 2013; 54(7):1761-75. PMC: 3679380. DOI: 10.1194/jlr.R030833. View

Berry D, OByrne S, Vreeland A, Blaner W, Noy N . Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6. Mol Cell Biol. 2012; 32(15):3164-75. PMC: 3434520. DOI: 10.1128/MCB.00505-12. View

Arnhold T, Tzimas G, Wittfoht W, Plonait S, Nau H . Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption. Life Sci. 1996; 59(12):PL169-77. DOI: 10.1016/0024-3205(96)00408-0. View

Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L . Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis. 1999; 143(2):427-34. DOI: 10.1016/s0021-9150(98)00303-7. View

Redgrave T . Chylomicron metabolism. Biochem Soc Trans. 2004; 32(Pt 1):79-82. DOI: 10.1042/bst0320079. View

Alapatt P, Guo F, Komanetsky S, Wang S, Cai J, Sargsyan A . Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem. 2012; 288(2):1250-65. PMC: 3543007. DOI: 10.1074/jbc.M112.369132. View

10.

Haskell M, Handelman G, Peerson J, Jones A, Rabbi M, Awal M . Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin A concentration in Bangladeshi surgical patients. Am J Clin Nutr. 1997; 66(1):67-74. DOI: 10.1093/ajcn/66.1.67. View

11.

Kotnik P, Fischer-Posovszky P, Wabitsch M . RBP4: a controversial adipokine. Eur J Endocrinol. 2011; 165(5):703-11. DOI: 10.1530/EJE-11-0431. View

12.

Quadro L, Blaner W, Salchow D, Vogel S, Piantedosi R, Gouras P . Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999; 18(17):4633-44. PMC: 1171537. DOI: 10.1093/emboj/18.17.4633. View

13.

Tanumihardjo S, Furr H, Olson J . Retinyl ester (vitamin A ester) and carotenoid composition in human liver. Int J Vitam Nutr Res. 1990; 60(4):307-13. View

14.

OByrne S, Blaner W . Retinol and retinyl esters: biochemistry and physiology. J Lipid Res. 2013; 54(7):1731-43. PMC: 3679378. DOI: 10.1194/jlr.R037648. View

15.

Seeliger M, Biesalski H, Wissinger B, Gollnick H, Gielen S, Frank J . Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Invest Ophthalmol Vis Sci. 1999; 40(1):3-11. View

16.

Paik J, During A, Harrison E, Mendelsohn C, Lai K, Blaner W . Expression and characterization of a murine enzyme able to cleave beta-carotene. The formation of retinoids. J Biol Chem. 2001; 276(34):32160-8. DOI: 10.1074/jbc.M010086200. View

17.

Blomhoff R, Holte K, Naess L, Berg T . Newly administered [3H]retinol is transferred from hepatocytes to stellate cells in liver for storage. Exp Cell Res. 1984; 150(1):186-93. DOI: 10.1016/0014-4827(84)90713-4. View

18.

Biesalski H, Frank J, Beck S, Heinrich F, Illek B, Reifen R . Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am J Clin Nutr. 1999; 69(5):931-6. DOI: 10.1093/ajcn/69.5.931. View

19.

West Jr K, Katz J, Khatry S, LeClerq S, Pradhan E, Shrestha S . Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ. 1999; 318(7183):570-5. PMC: 27760. DOI: 10.1136/bmj.318.7183.570. View

20.

Cooper A . Hepatic clearance of plasma chylomicron remnants. Semin Liver Dis. 1992; 12(4):386-96. DOI: 10.1055/s-2008-1040408. View