Effect of CAL-101, a PI3Kδ Inhibitor, on Ribosomal Rna Synthesis and Cell Proliferation in Acute Myeloid Leukemia Cells

Overview

Journal Blood Cancer J

Date 2014 Jul 12

PMID 25014775

Citations 10

Authors

L X T Nguyen

A Sesay

B S Mitchell

Affiliations

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References

James M, Zomerdijk J . Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients. J Biol Chem. 2003; 279(10):8911-8. DOI: 10.1074/jbc.M307735200. View

Park S, Chapuis N, Tamburini J, Bardet V, Cornillet-Lefebvre P, Willems L . Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia. Haematologica. 2009; 95(5):819-28. PMC: 2864389. DOI: 10.3324/haematol.2009.013797. View

Ryningen A, Reikvam H, Nepstad I, Rye K, Bruserud O . Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress. Bone Marrow Res. 2012; 2012:329061. PMC: 3467767. DOI: 10.1155/2012/329061. View

Fruman D, Rommel C . PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic. Cancer Discov. 2012; 1(7):562-72. DOI: 10.1158/2159-8290.CD-11-0249. View

Lannutti B, Meadows S, Herman S, Kashishian A, Steiner B, Johnson A . CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2010; 117(2):591-4. PMC: 3694505. DOI: 10.1182/blood-2010-03-275305. View

Berger A, Hoelbl-Kovacic A, Bourgeais J, Hoefling L, Warsch W, Grundschober E . PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia. 2013; 28(3):629-41. PMC: 3948164. DOI: 10.1038/leu.2013.351. View

Passegue E, Jamieson C, Ailles L, Weissman I . Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?. Proc Natl Acad Sci U S A. 2003; 100 Suppl 1:11842-9. PMC: 304096. DOI: 10.1073/pnas.2034201100. View

Zhao S, Konopleva M, Cabreira-Hansen M, Xie Z, Hu W, Milella M . Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia. 2003; 18(2):267-75. DOI: 10.1038/sj.leu.2403220. View

Min Y, Eom J, Cheong J, Maeng H, Kim J, Jeung H . Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia. 2003; 17(5):995-7. DOI: 10.1038/sj.leu.2402874. View

10.

Schwamb J, Feldhaus V, Baumann M, Patz M, Brodesser S, Brinker R . B-cell receptor triggers drug sensitivity of primary CLL cells by controlling glucosylation of ceramides. Blood. 2012; 120(19):3978-85. DOI: 10.1182/blood-2012-05-431783. View

11.

Brandts C, Sargin B, Rode M, Biermann C, Lindtner B, Schwable J . Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res. 2005; 65(21):9643-50. DOI: 10.1158/0008-5472.CAN-05-0422. View

12.

Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick J, Prie N, Verdier F . Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia. Blood. 2005; 106(3):1063-6. DOI: 10.1182/blood-2004-08-3225. View

13.

Truong Nguyen L, Mitchell B . Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA. Proc Natl Acad Sci U S A. 2013; 110(51):20681-6. PMC: 3870716. DOI: 10.1073/pnas.1313097110. View

14.

Montanaro L, Trere D, Derenzini M . Nucleolus, ribosomes, and cancer. Am J Pathol. 2008; 173(2):301-10. PMC: 2475768. DOI: 10.2353/ajpath.2008.070752. View

15.

Perl A, Kasner M, Shank D, Luger S, Carroll M . Single-cell pharmacodynamic monitoring of S6 ribosomal protein phosphorylation in AML blasts during a clinical trial combining the mTOR inhibitor sirolimus and intensive chemotherapy. Clin Cancer Res. 2011; 18(6):1716-25. PMC: 3306511. DOI: 10.1158/1078-0432.CCR-11-2346. View

16.

Smith M, Barnett M, Bassan R, Gatta G, Tondini C, Kern W . Adult acute myeloid leukaemia. Crit Rev Oncol Hematol. 2004; 50(3):197-222. DOI: 10.1016/j.critrevonc.2003.11.002. View

17.

Allo S, McDermott P, Carl L, Morgan H . Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription. Role in hypertrophic growth of cultured cardiomyocytes. J Biol Chem. 1991; 266(32):22003-9. View