Comparison of Mutations in Lung, Colorectal and Gastric Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2014 Jul 12

PMID 25013470

Citations 10

Authors

Nanqiu Peng

Xintai Zhao

Affiliations

Soon will be listed here.

Abstract

is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to compare mutation in different types of cancer. Nested and COLD-PCR were used to detect mutations. The Chi-squared test was used for statistical analysis. In this study, the total mutation frequency was found to be 9.09, 18.61 and 6.67% in lung, colorectal and gastric cancer, respectively. Similar mutation frequencies were detected among sample types and genders for lung and gastric cancer, with the exception of colorectal cancer. However, age had no impact on the mutation rates.

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