Glycan Based Detection and Drug Susceptibility of Influenza Virus

Overview

Journal Anal Chem

Specialty Chemistry

Date 2014 Jul 10

PMID 25007351

Citations 6

Authors

Hieu Dinh

Xiaohu Zhang

Joyce Sweeney

Yang Yang

Yun He

Abasaheb Dhawane

Suri S Iyer

Affiliations

Soon will be listed here.

Abstract

We have developed a panel of synthetic glycans as receptor mimics for the specific capture of influenza viruses. The glycans were printed onto commercial glass slides using a free amine at the end of a spacer to generate a small focused microarray. The microarray was evaluated for its ability to capture three different strains of influenza A virus, two H1N1, A/Brisbane/59/2007 and A/Solomon Islands/3/2006 and one H3N2, A/Aichi/2/1968. We observed an excellent detection ability with some compounds exhibiting clinically relevant (10(1) plaque forming units) limit of detection. We also tested the drug susceptibility of current antivirals, Zanamivir and Ostelamivir using this microarray and could determine antiviral resistance for these strains.

Citing Articles

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