Comparative Transcriptome Analysis Reveals Significant Differences in MicroRNA Expression and Their Target Genes Between Adipose and Muscular Tissues in Cattle

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jul 10

PMID 25006962

Citations 14

Authors

Jiajie Sun

Bowen Zhang

Xianyong Lan

Chunlei Zhang

Chuzhao Lei

Hong Chen

Affiliations

Soon will be listed here.

Abstract

The posttranscriptional gene regulation mediated by microRNAs (miRNAs) plays an important role in various species. However, to date limited miRNAs have been reported between fat and muscle tissues in beef cattle. In this paper, 412 known and 22 novel miRNAs in backfat as well as 334 known and 10 novel miRNAs in longissimus thoracis were identified in the Chinese Qinchuan beef cattle. Bta-miR-199a-3p, -154c, -320a and -432 were expressed at higher levels in backfat tissue, while bta-miR-1, -133a, -206, and -378 were also significantly enriched in muscle tissue. Functional analysis revealed that fat-enriched miRNAs targeted PRKAA1/2, PPARA and PPARG genes to modulate lipid and fatty acid metabolism, and muscle-enriched miRNAs targeted CSRP3 gene to present function involved in skeletal and muscular system development. The results obtained may help in the design of new selection strategies to improve beef quality.

Citing Articles

Comparative analysis of the whole transcriptome landscapes of muscle and adipose tissue in Qinchuan beef cattle.

Qiu J, Ma Z, Hong Z, Yin X, Chen Y, Ahmed H BMC Genomics. 2025; 26(1):32.

PMID: 39810084 PMC: 11731550. DOI: 10.1186/s12864-025-11223-7.

Association of plasma miRNAs with early life performance and aging in dairy cattle.

MacLeay M, Banos G, Donadeu F PLoS One. 2023; 18(7):e0288343.

PMID: 37428722 PMC: 10332601. DOI: 10.1371/journal.pone.0288343.

MiRNA-Seq reveals key MicroRNAs involved in fat metabolism of sheep liver.

Fei X, Jin M, Yuan Z, Li T, Lu Z, Wang H Front Genet. 2023; 14:985764.

PMID: 36968587 PMC: 10035661. DOI: 10.3389/fgene.2023.985764.

MiR-107 Regulates Adipocyte Differentiation and Adipogenesis by Targeting Apolipoprotein C-2 () in Bovine.

Wei X, Zhao X, Shan X, Zhu Y, Wang S, Chen H Genes (Basel). 2022; 13(8).

PMID: 36011378 PMC: 9407703. DOI: 10.3390/genes13081467.

Transcriptome reveals key microRNAs involved in fat deposition between different tail sheep breeds.

Fei X, Jin M, Wang Y, Li T, Lu Z, Yuan Z PLoS One. 2022; 17(3):e0264804.

PMID: 35231067 PMC: 8887763. DOI: 10.1371/journal.pone.0264804.

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