Emerging Role of Long Non-coding RNA SOX2OT in SOX2 Regulation in Breast Cancer

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Jul 10

PMID 25006803

Citations 80

Authors

Marjan E Askarian-Amiri

Vahid Seyfoddin

Chanel E Smart

Jingli Wang

Ji Eun Kim

Herah Hansji

Bruce C Baguley

Graeme J Finlay

Euphemia Y Leung

Affiliations

Soon will be listed here.

Abstract

The transcription factor SOX2 is essential for maintaining pluripotency in a variety of stem cells. It has important functions during embryonic development, is involved in cancer stem cell maintenance, and is often deregulated in cancer. The mechanism of SOX2 regulation has yet to be clarified, but the SOX2 gene lies in an intron of a long multi-exon non-coding RNA called SOX2 overlapping transcript (SOX2OT). Here, we show that the expression of SOX2 and SOX2OT is concordant in breast cancer, differentially expressed in estrogen receptor positive and negative breast cancer samples and that both are up-regulated in suspension culture conditions that favor growth of stem cell phenotypes. Importantly, ectopic expression of SOX2OT led to an almost 20-fold increase in SOX2 expression, together with a reduced proliferation and increased breast cancer cell anchorage-independent growth. We propose that SOX2OT plays a key role in the induction and/or maintenance of SOX2 expression in breast cancer.

Citing Articles

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