Association of Arterial Stiffness and Osteoporosis in Healthy Men Undergoing Screening Medical Examination

Overview

Journal J Bone Metab

Date 2014 Jul 10

PMID 25006570

Citations 8

Authors

Nam Lee Kim

Ha Min Jang

Sul Ki Kim

Ki Dong Ko

In Cheol Hwang

Heuy Sun Suh

Affiliations

Soon will be listed here.

Abstract

Background: Association of arterial stiffness and osteoporosis has been previously reported in women. However, this association is still controversial for men. Therefore, we investigated correlation of arterial stiffness and osteoporosis by measuring brachial-ankle (ba) pulse wave velocity (PWV) and bone mineral density (BMD).

Methods: We reviewed medical charts of 239 people (women: 128, men: 111) who visited the Health Promotion Center, retrospectively. ba-PWV was measured by automatic wave analyzer. Lumbar spine (L1-L4) BMD and femur BMD were measured by dual energy X-ray absorptiometry. Metabolic syndrome was based on the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATPIII) definition. Body mass index (BMI)>25 kg/m(2) was used instead of waist circumference.

Results: In Pearson's correlation analysis, PWV and femur BMD (Neck, total) had a significant inverse relationship in men (r=-0.254, P=0.007; r=-0.202, P=0.034). In women, PWV and the L-spine, femur (Neck, total) had a significant inverse relationship. (r=-0.321, P<0.001; r=-0.189, P=0.032; r=-0.177, P=0.046) Age and PWV showed the greatest association in both men and women (r=0.46 P<0.001; r=0.525, P<0.001) In multiple regression analysis, the L-spine BMD and PWV had an independent relationship in women after adjusting for age, metabolic syndrome, BMI, smoking, drinking and exercise. (r=-0.229, P=0.015). No independent association was found between PWV and BMD in men.

Conclusions: The association between arterial stiffness and BMD was confirmed in women. However, this association was not statistically significant for men.

Citing Articles

Links between arterial stiffness and bone mineral density in middle-aged and elderly Chinese individuals: a cross-sectional study.

Zhang M, Bai L, Kang J, Ge J, Peng W BMJ Open. 2019; 9(8):e029946.

PMID: 31401606 PMC: 6701650. DOI: 10.1136/bmjopen-2019-029946.

Osteoporosis is inversely associated with arterial stiffness in the elderly: An investigation using the Osteoporosis Self-assessment Tool for Asians index in an elderly Chinese cohort.

Xuan Y, Wang W, Zhang H, Tan I, Butlin M, Avolio A J Clin Hypertens (Greenwich). 2019; 21(3):405-411.

PMID: 30734463 PMC: 8030380. DOI: 10.1111/jch.13493.

Bone metabolism markers are associated with neck circumference in adult Arab women.

Albassam R, Sabico S, Alnaami A, Khattak M, Lei K, Al-Daghri N Osteoporos Int. 2019; 30(4):845-852.

PMID: 30613867 DOI: 10.1007/s00198-018-04830-6.

The Association between Bone Quality and Atherosclerosis: Results from Two Large Population-Based Studies.

Lange V, Dorr M, Schminke U, Volzke H, Nauck M, Wallaschofski H Int J Endocrinol. 2017; 2017:3946569.

PMID: 28852407 PMC: 5568612. DOI: 10.1155/2017/3946569.

Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension.

Li X, He H, Zhao Y, Li Y, Liu Z, Liu T J Clin Hypertens (Greenwich). 2016; 18(11):1106-1111.

PMID: 27255660 PMC: 8031899. DOI: 10.1111/jch.12848.

References

Yoshimura N, Kinoshita H, Danjoh S, Takijiri T, Morioka S, Kasamatsu T . Bone loss at the lumbar spine and the proximal femur in a rural Japanese community, 1990-2000: the Miyama study. Osteoporos Int. 2002; 13(10):803-8. DOI: 10.1007/s001980200111. View

Marcovitz P, Tran H, Franklin B, ONeill W, Yerkey M, Boura J . Usefulness of bone mineral density to predict significant coronary artery disease. Am J Cardiol. 2005; 96(8):1059-63. DOI: 10.1016/j.amjcard.2005.06.034. View

Maziere C, Louvet L, Gomila C, Kamel S, Massy Z, Maziere J . Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. J Cell Physiol. 2009; 221(3):572-8. DOI: 10.1002/jcp.21886. View

Meguro T, Nagatomo Y, Nagae A, Seki C, Kondou N, Shibata M . Elevated arterial stiffness evaluated by brachial-ankle pulse wave velocity is deleterious for the prognosis of patients with heart failure. Circ J. 2009; 73(4):673-80. DOI: 10.1253/circj.cj-08-0350. View

Hirose K, Tomiyama H, Okazaki R, Arai T, Koji Y, Zaydun G . Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia. J Clin Endocrinol Metab. 2003; 88(6):2573-8. DOI: 10.1210/jc.2002-021511. View

Frost M, Grella R, Millasseau S, Jiang B, Hampson G, Fogelman I . Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening. Calcif Tissue Int. 2008; 83(2):112-20. DOI: 10.1007/s00223-008-9153-2. View

Weng C, Yuan H, Tang X, Huang Z, Yang K, Chen W . Age- and gender dependent association between components of metabolic syndrome and subclinical arterial stiffness in a Chinese population. Int J Med Sci. 2012; 9(8):730-7. PMC: 3477683. DOI: 10.7150/ijms.4752. View

van der Klift M, Pols H, Hak A, Witteman J, Hofman A, de Laet C . Bone mineral density and the risk of peripheral arterial disease: the Rotterdam Study. Calcif Tissue Int. 2002; 70(6):443-9. DOI: 10.1007/s00223-001-2076-9. View

Hak A, Pols H, van Hemert A, Hofman A, Witteman J . Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol. 2000; 20(8):1926-31. DOI: 10.1161/01.atv.20.8.1926. View

10.

Demer L . Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids. Int J Epidemiol. 2002; 31(4):737-41. DOI: 10.1093/ije/31.4.737. View

11.

Browner W, Lui L, Cummings S . Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women. J Clin Endocrinol Metab. 2001; 86(2):631-7. DOI: 10.1210/jcem.86.2.7192. View

12.

Sugawara J, Hayashi K, Yokoi T, Cortez-Cooper M, DeVan A, Anton M . Brachial-ankle pulse wave velocity: an index of central arterial stiffness?. J Hum Hypertens. 2005; 19(5):401-6. DOI: 10.1038/sj.jhh.1001838. View

13.

Looker A, Borrud L, Hughes J, Fan B, Shepherd J, Melton 3rd L . Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area: United States, 2005-2008. Vital Health Stat 11. 2013; (251):1-132. View

14.

Kado D, Browner W, Blackwell T, Gore R, Cummings S . Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res. 2000; 15(10):1974-80. DOI: 10.1359/jbmr.2000.15.10.1974. View

15.

Giallauria F, Milaneschi Y, Tanaka T, Maggio M, Canepa M, Elango P . Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging. J Clin Endocrinol Metab. 2012; 97(10):3717-23. PMC: 3674293. DOI: 10.1210/jc.2012-1584. View

16.

Mikumo M, Okano H, Yoshikata R, Ishitani K, Ohta H . Association between lumbar bone mineral density and vascular stiffness as assessed by pulse wave velocity in postmenopausal women. J Bone Miner Metab. 2008; 27(1):89-94. DOI: 10.1007/s00774-008-0014-x. View

17.

Magnus J, Broussard D . Relationship between bone mineral density and myocardial infarction in US adults. Osteoporos Int. 2005; 16(12):2053-62. DOI: 10.1007/s00198-005-1999-9. View

18.

Gourdy P, Calippe B, Laurell H, Tremollieres F, Douin-Echinard V, Lenfant F . Role of inflammatory cytokines in the effect of estradiol on atheroma. Clin Exp Pharmacol Physiol. 2008; 35(4):396-401. DOI: 10.1111/j.1440-1681.2008.04885.x. View

19.

Lee H, Shin J, Lim Y, Kim B, Kim Y, Lee J . The relationship between coronary artery calcification and bone mineral density in patients according to their metabolic syndrome status. Korean Circ J. 2011; 41(2):76-82. PMC: 3053564. DOI: 10.4070/kcj.2011.41.2.76. View

20.

Kitahara T, Ono K, Tsuchida A, Kawai H, Shinohara M, Ishii Y . Impact of brachial-ankle pulse wave velocity and ankle-brachial blood pressure index on mortality in hemodialysis patients. Am J Kidney Dis. 2005; 46(4):688-96. DOI: 10.1053/j.ajkd.2005.06.016. View