A Review of Selected Candidate Endophenotypes for Depression

Overview

Journal Clin Psychol Rev

Specialty Psychology

Date 2014 Jul 10

PMID 25006008

Citations 49

Authors

Brandon L Goldstein

Daniel N Klein

Affiliations

Soon will be listed here.

Abstract

Endophenotypes are proposed to occupy an intermediate position in the pathway between genotype and phenotype in genetically complex disorders such as depression. To be considered an endophenotype, a construct must meet a set of criteria proposed by Gottesman and Gould (2003). In this qualitative review, we summarize evidence for each criterion for several putative endophenotypes for depression: neuroticism, morning cortisol, frontal asymmetry of cortical electrical activity, reward learning, and biases of attention and memory. Our review indicates that while there is strong support for some depression endophenotypes, other putative endophenotypes lack data or have inconsistent findings for core criteria.

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