Concise Review of Recent Studies in Vitiligo

Overview

Journal Qatar Med J

Specialty General Medicine

Date 2014 Jul 9

PMID 25003059

Citations 16

Authors

Mohamed Allam

Hassan Riad

Affiliations

Soon will be listed here.

Abstract

Vitiligo is an acquired pigmentry disorder of the skin and mucous membranes which manifests as white macules and patches due to selective loss of melanocytes. Etiological hypotheses of vitiligo include genetic, immunological, neurohormonal, cytotoxic, biochemical, oxidative stress and newer theories of melanocytorrhagy and decreased melanocytes survival. There are several types of vitiligo which are usually diagnosed clinically and by using a Wood's lamp; also vitiligo may be associated with autoimmune diseases, audiological and ophthalmological findings or it can be a part of polyendocrinopathy syndromes. Several interventions are available for the treatment for vitiligo to stop disease progression and/or to attain repigmentation or even depigmentation. In this article, we will present an overall view of current standing of vitiligo research work especially in the etiological factors most notably the genetic components, also, types and associations and various and newer treatment modalities.

Citing Articles

Dietary Interventions, Supplements, and Plant-Derived Compounds for Adjunct Vitiligo Management: A Review of the Literature.

Diaz M, Tran J, Rose D, Wei A, Lakshmipathy D, Lipner S Nutrients. 2025; 17(2).

PMID: 39861486 PMC: 11767946. DOI: 10.3390/nu17020357.

Vitamin D Receptor Gene Polymorphisms and Association with Vitiligo in Indonesian Population.

Maharani R, Dharmadji H, Hindritiani R, Achdiat P, Gunawan H, Dwiyana R Appl Clin Genet. 2023; 16:225-232.

PMID: 38146530 PMC: 10749542. DOI: 10.2147/TACG.S435016.

Silver Nanoparticles and (Licorice) Root Extract as Modifying Agents of Hydrogels Designed as Innovative Dressings.

Kedzierska M, Bankosz M, Drabczyk A, Kudlacik-Kramarczyk S, Jamrozy M, Potemski P Int J Mol Sci. 2023; 24(1).

PMID: 36613661 PMC: 9820111. DOI: 10.3390/ijms24010217.

Discovery of Pinostrobin as a Melanogenic Agent in cAMP/PKA and p38 MAPK Signaling Pathway.

Yoon J, Youn K, Jun M Nutrients. 2022; 14(18).

PMID: 36145089 PMC: 9504415. DOI: 10.3390/nu14183713.

Fractional Carbon Dioxide Laser versus Fractional Carbon Dioxide Laser with Autologous Intralesional Platelet-rich Plasma in the Treatment of Stable, Non-segmental Vitiligo: A Randomized Comparative Study.

Raizada A, Panda M, Singh B, Kar B J Cutan Aesthet Surg. 2021; 14(1):55-63.

PMID: 34084009 PMC: 8149972. DOI: 10.4103/JCAS.JCAS_188_19.

References

Birol A, Kisa U, Kurtipek G, Kara F, Kocak M, Erkek E . Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo. Int J Dermatol. 2006; 45(8):992-3. DOI: 10.1111/j.1365-4632.2006.02744.x. View

Talsania N, Lamb B, Bewley A . Vitiligo is more than skin deep: a survey of members of the Vitiligo Society. Clin Exp Dermatol. 2009; 35(7):736-9. DOI: 10.1111/j.1365-2230.2009.03765.x. View

Agrawal K, Agrawal A . Vitiligo: repigmentation with dermabrasion and thin split-thickness skin graft. Dermatol Surg. 1995; 21(4):295-300. DOI: 10.1111/j.1524-4725.1995.tb00176.x. View

Kyriakis K, Palamaras I, Tsele E, Michailides C, Terzoudi S . Case detection rates of vitiligo by gender and age. Int J Dermatol. 2009; 48(3):328-9. DOI: 10.1111/j.1365-4632.2009.03770.x. View

El Mofty M, Mostafa W, Esmat S, Youssef R, Azzam O, Hunter N . Narrow band Ultraviolet B 311 nm in the treatment of vitiligo: two right-left comparison studies. Photodermatol Photoimmunol Photomed. 2006; 22(1):6-11. DOI: 10.1111/j.1600-0781.2006.00189.x. View

Simon J, Burgos-Vargas R . Vitiligo improvement in a patient with ankylosing spondylitis treated with infliximab. Dermatology. 2008; 216(3):234-5. DOI: 10.1159/000112932. View

Alikhan A, Felsten L, Daly M, Petronic-Rosic V . Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011; 65(3):473-491. DOI: 10.1016/j.jaad.2010.11.061. View

Klarquist J, Denman C, Hernandez C, Wainwright D, Wainwright D, Strickland F . Reduced skin homing by functional Treg in vitiligo. Pigment Cell Melanoma Res. 2010; 23(2):276-86. PMC: 3778930. DOI: 10.1111/j.1755-148X.2010.00688.x. View

Ostovari N, Passeron T, Lacour J, Ortonne J . Lack of efficacy of tacrolimus in the treatment of vitiligo in the absence of UV-B exposure. Arch Dermatol. 2006; 142(2):252-3. DOI: 10.1001/archderm.142.2.252. View

10.

Hartmann A, Brocker E, Hamm H . Occlusive treatment enhances efficacy of tacrolimus 0.1% ointment in adult patients with vitiligo: results of a placebo-controlled 12-month prospective study. Acta Derm Venereol. 2008; 88(5):474-9. DOI: 10.2340/00015555-0464. View

11.

Pancar Yuksel E, Aydin F, Senturk N, Canturk T, Turanli A . Comparison of the efficacy of narrow band ultraviolet B and narrow band ultraviolet B plus topical catalase-superoxide dismutase treatment in vitiligo patients. Eur J Dermatol. 2009; 19(4):341-4. DOI: 10.1684/ejd.2009.0699. View

12.

Mazereeuw-Hautier J, Bezio S, Mahe E, Bodemer C, Eschard C, Viseux V . Segmental and nonsegmental childhood vitiligo has distinct clinical characteristics: a prospective observational study. J Am Acad Dermatol. 2010; 62(6):945-9. DOI: 10.1016/j.jaad.2009.06.081. View

13.

Rao J, Fitzpatrick R . Use of the Q-switched 755-nm alexandrite laser to treat recalcitrant pigment after depigmentation therapy for vitiligo. Dermatol Surg. 2004; 30(7):1043-5. DOI: 10.1111/j.1524-4725.2004.30313.x. View

14.

Liu J, Tang H, Zuo X, Liang B, Wang P, Sun L . A single nucleotide polymorphism rs9468925 of MHC region is associated with clinical features of generalized vitiligo in Chinese Han population. J Eur Acad Dermatol Venereol. 2011; 26(9):1137-41. DOI: 10.1111/j.1468-3083.2011.04259.x. View

15.

Sassi F, Cazzaniga S, Tessari G, Chatenoud L, Reseghetti A, Marchesi L . Randomized controlled trial comparing the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in the treatment of vitiligo of the face and neck. Br J Dermatol. 2008; 159(5):1186-91. DOI: 10.1111/j.1365-2133.2008.08793.x. View

16.

Birlea S, Jin Y, Bennett D, Herbstman D, Wallace M, McCormack W . Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP. J Invest Dermatol. 2010; 131(2):371-81. PMC: 3172683. DOI: 10.1038/jid.2010.337. View

17.

Westerhof W, Nieuweboer-Krobotova L, Mulder P, Glazenburg E . Left-right comparison study of the combination of fluticasone propionate and UV-A vs. either fluticasone propionate or UV-A alone for the long-term treatment of vitiligo. Arch Dermatol. 1999; 135(9):1061-6. DOI: 10.1001/archderm.135.9.1061. View

18.

Spritz R . The genetics of generalized vitiligo: autoimmune pathways and an inverse relationship with malignant melanoma. Genome Med. 2010; 2(10):78. PMC: 2988443. DOI: 10.1186/gm199. View

19.

Lahiri K, Malakar S, Sarma N, Banerjee U . Repigmentation of vitiligo with punch grafting and narrow-band UV-B (311 nm)--a prospective study. Int J Dermatol. 2006; 45(6):649-55. DOI: 10.1111/j.1365-4632.2005.02697.x. View

20.

Leite R, Craveiro Leite A . Two therapeutic challenges: periocular and genital vitiligo in children successfully treated with pimecrolimus cream. Int J Dermatol. 2007; 46(9):986-9. DOI: 10.1111/j.1365-4632.2007.03282.x. View