Malignant Transformation of Uterine Leiomyoma

Overview

Journal Qatar Med J

Specialty General Medicine

Date 2014 Jul 9

PMID 25003044

Citations 8

Authors

Afaf A Al Ansari

Fatima A Al Hail

Emad Abboud

Affiliations

Soon will be listed here.

Abstract

A rare case of malignant transformation of uterine leiomyoma is reported. A 54 year old lady, nulliparous and 2 years postmenopausal presented to gynecology clinic with a pelvi - abdominal mass and ultrasound scan suggestive of multiple uterine fibroid. Total abdominal hysterectomy performed. Histopathology report showed leiomyosarcomative changes from benign leiomyoma within the huge mass.

Citing Articles

Navigating diagnostic challenges: case reports on differentiating uterine fibroids from leiomyosarcoma through imaging and clinical evaluation.

Algeri P, Adorni M, Besana G, Carlini L, Ciammella M, Garbo S J Ultrasound. 2025; .

PMID: 39904952 DOI: 10.1007/s40477-025-00991-3.

Accuracy of the Measurement of Uterine Leiomyoma by Transabdominal Ultrasonography.

Oue K, Matsuda M, Ichimura T, Murakami M, Kawamura N, Sumi T Cureus. 2024; 16(8):e68193.

PMID: 39221293 PMC: 11363503. DOI: 10.7759/cureus.68193.

Comprehensive Review of Uterine Leiomyosarcoma: Pathogenesis, Diagnosis, Prognosis, and Targeted Therapy.

Yang Q, Madueke-Laveaux O, Cun H, Wlodarczyk M, Garcia N, Carvalho K Cells. 2024; 13(13.

PMID: 38994959 PMC: 11240800. DOI: 10.3390/cells13131106.

Pathways of Hypoxia-Inducible Factor (HIF) in the Orchestration of Uterine Fibroids Development.

Fedotova M, Barysheva E, Bushueva O Life (Basel). 2023; 13(8).

PMID: 37629598 PMC: 10456109. DOI: 10.3390/life13081740.

A transcriptome-wide association study of uterine fibroids to identify potential genetic markers and toxic chemicals.

Kim G, Jang G, Song J, Kim D, Lee S, Joo J PLoS One. 2022; 17(9):e0274879.

PMID: 36174000 PMC: 9521910. DOI: 10.1371/journal.pone.0274879.

References

Scurry J, Hack M . Leiomyosarcoma arising in a lipoleiomyoma. Gynecol Oncol. 1990; 39(3):381-3. DOI: 10.1016/0090-8258(90)90271-l. View

Mayerhofer K, Obermair A, Windbichler G, Petru E, Kaider A, Hefler L . Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases. Gynecol Oncol. 1999; 74(2):196-201. DOI: 10.1006/gyno.1999.5436. View

Rotmensch J, Bosnyak S, Montag A . Malignant transition of uterine leiomyomata. Int J Gynaecol Obstet. 1993; 42(1):47-9. DOI: 10.1016/0020-7292(93)90449-7. View

Reiter R, Wagner P, Gambone J . Routine hysterectomy for large asymptomatic uterine leiomyomata: a reappraisal. Obstet Gynecol. 1992; 79(4):481-4. View

Gard G, Mulvany N, Quinn M . Management of uterine leiomyosarcoma in Australia. Aust N Z J Obstet Gynaecol. 1999; 39(1):93-8. DOI: 10.1111/j.1479-828x.1999.tb03453.x. View