Neuroprotection of Up-regulated Carbon Monoxide by Electrical Acupuncture on Perinatal Hypoxic-ischemic Brain Damage in Rats

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2014 Jul 9

PMID 25002029

Citations 8

Authors

Yichen Liu

Zhihui Li

Xiuyu Shi

Ying Liu

Weiguang Li

Guofang Duan

Hualing Li

Xiaofan Yang

Chenggang Zhang

Liping Zou

Affiliations

Soon will be listed here.

Abstract

This study investigated the neuroprotection and potential mechanism of carbon monoxide (CO) against perinatal hypoxic-ischemic brain damage in rats by electrical acupuncture (EA). Animal behavior, morphological changes, cystathionine beta-synthase (CBS), hypoxia-inducible factor-1α (HIF-1α), and heme oxygenase-1 (HO-1) expression levels, and CO content in rat cortex cells were determined. Results demonstrated that EA treatment decreased the slope behavior and increased the overhang behavior of perinatal rats. The treatment also decreased the number of positive cells. The activator and inhibitor of CBS aggravated and remitted the hypoxic damage in cortex cells, respectively. EA treatment decreased CBS expression level and increased HO-1 and HIF-1α expression levels in perinatal rat cortex cells. Compared with the control groups, the CO content of cortex cells in the EA treatment group significantly increased (**p < 0.01). We hypothesized that EA treatment increases cortical CO content to protect against hypoxic damage via the hydrogen sulfide/CBS-CO/HO-1-HIF-1α system. This study provided a significant reference for EA therapy and cued a novel protective mechanism for cerebral palsy.

Citing Articles

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CBS-Induced HS Generation in Hippocampus Inhibits EA-Induced Analgesia.

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Inhaled Gases for Neuroprotection of Neonates: A Review.

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