Nephroprotective Activities of Quercetin with Potential Relevance to Oxidative Stress Induced by Valproic Acid

Overview

Journal Protoplasma

Publisher Springer

Specialty Biology

Date 2014 Jul 9

PMID 25000991

Citations 22

Authors

Shaista Chaudhary

Pratibha Ganjoo

Sheikh Raiusddin

Suhel Parvez

Affiliations

Soon will be listed here.

Abstract

Valproic acid (VPA) is ubiquitously used as a major drug in the intervention of epilepsy and in the control of several kinds of seizures. Cellular toxicities are the serious dose-limiting side effects of VPA when applied in the treatment of diseases. Oxidative stress has been proven to be involved in VPA-induced toxicity. Accumulating evidence intimates that oxidative stress caused by free radicals and in kidney cells contributes to the pathogenesis of VPA-induced nephrotoxicity. The pathogenesis of these forms of VPA nephrotoxicity is still not clear. The aim of our investigation was to evaluate the nephrotoxic potential of VPA and protective effects of quercetin (QR) against VPA-induced nephrotoxicity by using rat kidney tissue preparation as an in vitro model. Oxidative stress indexes such as lipid peroxidation (LPO) and protein carbonyl (PC) content were appraised. The levels of oxidative stress markers, LPO, and PC were significantly elevated. Nonenzymatic antioxidants effect was also demonstrated as a significant increase in reduced glutathione (GSH) and nonprotein thiol level (NP-SH). VPA exposure altered the activities of glutathione metabolizing enzymes such as glutathione-S-transferase, glutathione peroxidase, and glutathione reductase. Pre-treatment with QR could reverse the VPA-induced effects in kidney tissue preparation of rat. Based on reno-protective and antioxidant action of QR, we suggest that this flavonoid compound could be considered as a potential safe and effective approach in attenuating the adverse effect of VPA-induced nephrotoxicity.

Citing Articles

Role of Nrf2/HO-1 and cytoglobin signaling in the protective effect of indole-3-acetic acid and chenodeoxycholic acid against kidney injury induced by valproate.

Alhusaini A, Sarawi W, Mukhtar N, Aljubeiri D, Aljarboa A, Alduhailan H Heliyon. 2025; 10(24):e41069.

PMID: 39759289 PMC: 11697546. DOI: 10.1016/j.heliyon.2024.e41069.

Ameliorative effects of Edaravone against Valproic Acid-Induced kidney damage.

Bayrak B, Sancar S, Cakmak N, Bolkent S, Yanardag R J Mol Histol. 2024; 56(1):4.

PMID: 39601910 DOI: 10.1007/s10735-024-10291-5.

Role of Plant Phytochemicals: Resveratrol, Curcumin, Luteolin and Quercetin in Demyelination, Neurodegeneration, and Epilepsy.

Grabarczyk M, Justynska W, Czpakowska J, Smolinska E, Bielenin A, Glabinski A Antioxidants (Basel). 2024; 13(11).

PMID: 39594506 PMC: 11591432. DOI: 10.3390/antiox13111364.

Quercetin prophylaxis protects the kidneys by modulating the renin-angiotensin-aldosterone axis under acute hypobaric hypoxic stress.

Rathi V, Sagi S, Yadav A, Kumar M, Varshney R Sci Rep. 2024; 14(1):7617.

PMID: 38556603 PMC: 10982295. DOI: 10.1038/s41598-024-58134-3.

Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies.

Zeng Y, Li J, Wei X, Ma S, Wang Q, Qi Z Front Pharmacol. 2024; 14:1310023.

PMID: 38186644 PMC: 10770850. DOI: 10.3389/fphar.2023.1310023.

References

Zhu Y, Carvey P, Ling Z . Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 2006; 1090(1):35-44. PMC: 1868496. DOI: 10.1016/j.brainres.2006.03.063. View

Farombi E, Ekor M . Curcumin attenuates gentamicin-induced renal oxidative damage in rats. Food Chem Toxicol. 2006; 44(9):1443-8. DOI: 10.1016/j.fct.2006.05.005. View

Park H, Kim S, Kwon D, Park J, Kim Y . Protective effect of quercetin against paraquat-induced lung injury in rats. Life Sci. 2010; 87(5-6):181-6. DOI: 10.1016/j.lfs.2010.06.011. View

Fourcade S, Ruiz M, Guilera C, Hahnen E, Brichta L, Naudi A . Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy. Hum Mol Genet. 2010; 19(10):2005-14. DOI: 10.1093/hmg/ddq082. View

Kiang T, Teng X, Karagiozov S, Surendradoss J, Chang T, Abbott F . Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes. Toxicol Sci. 2010; 118(2):501-9. DOI: 10.1093/toxsci/kfq294. View

Renugadevi J, Prabu S . Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol. 2009; 62(5):471-81. DOI: 10.1016/j.etp.2009.06.006. View

Haque R, Bin-Hafeez B, Parvez S, Pandey S, Sayeed I, Ali M . Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamide-induced biochemical toxicity. Hum Exp Toxicol. 2003; 22(9):473-80. DOI: 10.1191/0960327103ht388oa. View

Prabu S, Shagirtha K, Renugadevi J . Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats. Eur Rev Med Pharmacol Sci. 2011; 14(11):903-14. View

Waseem M, Kaushik P, Parvez S . Mitochondria-mediated mitigatory role of curcumin in cisplatin-induced nephrotoxicity. Cell Biochem Funct. 2013; 31(8):678-84. DOI: 10.1002/cbf.2955. View

10.

Habig W, Pabst M, Jakoby W . Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249(22):7130-9. View

11.

Mariee A, Abd-Allah G, El-Beshbishy H . Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats. Pharm Biol. 2012; 50(8):1019-25. DOI: 10.3109/13880209.2012.655424. View

12.

Chang T, Abbott F . Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity. Drug Metab Rev. 2006; 38(4):627-39. DOI: 10.1080/03602530600959433. View

13.

Gravemann U, Volland J, Nau H . Hydroxamic acid and fluorinated derivatives of valproic acid: anticonvulsant activity, neurotoxicity and teratogenicity. Neurotoxicol Teratol. 2008; 30(5):390-4. DOI: 10.1016/j.ntt.2008.03.060. View

14.

Tabassum H, Parvez S, Rehman H, Banerjee B, Siemen D, Raisuddin S . Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. Hum Exp Toxicol. 2007; 26(6):509-18. DOI: 10.1177/0960327107072392. View

15.

Coskun O, Kanter M, Korkmaz A, Oter S . Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res. 2005; 51(2):117-23. DOI: 10.1016/j.phrs.2004.06.002. View

16.

Paul M, Abhilash M, Varghese M, Alex M, Nair R . Protective effects of α-tocopherol against oxidative stress related to nephrotoxicity by monosodium glutamate in rats. Toxicol Mech Methods. 2012; 22(8):625-30. DOI: 10.3109/15376516.2012.714008. View

17.

Khan S, Ahmad T, Parekh C, Trivedi P, Kushwaha S, Jena G . Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice. Reprod Toxicol. 2011; 32(4):385-94. DOI: 10.1016/j.reprotox.2011.09.007. View

18.

Spiller H, Krenzelok E, Klein-Schwartz W, Winter M, Weber J, Sollee D . Multicenter case series of valproic acid ingestion: serum concentrations and toxicity. J Toxicol Clin Toxicol. 2001; 38(7):755-60. DOI: 10.1081/clt-100102388. View

19.

Tong V, Teng X, Chang T, Abbott F . Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. Toxicol Sci. 2005; 86(2):427-35. DOI: 10.1093/toxsci/kfi184. View

20.

Abdel-Raheem I, Abdel-Ghany A, Mohamed G . Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull. 2009; 32(1):61-7. DOI: 10.1248/bpb.32.61. View